[HTML][HTML] EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis
KM Talasila, A Soentgerath, P Euskirchen… - Acta …, 2013 - Springer
Angiogenesis is regarded as a hallmark of cancer progression and it has been postulated
that solid tumor growth depends on angiogenesis. At present, however, it is clear that tumor …
that solid tumor growth depends on angiogenesis. At present, however, it is clear that tumor …
EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation
E Eskilsson, GV Rosland, KM Talasila… - Neuro …, 2016 - academic.oup.com
Background Amplification of the epidermal growth factor receptor (EGFR) and its mutant
EGFRvIII are among the most common genetic alterations in glioblastoma (GBM), the most …
EGFRvIII are among the most common genetic alterations in glioblastoma (GBM), the most …
The angiogenic switch leads to a metabolic shift in human glioblastoma
KM Talasila, GV Røsland, HR Hagland… - Neuro …, 2017 - academic.oup.com
Background. Invasion and angiogenesis are major hallmarks of glioblastoma (GBM) growth.
While invasive tumor cells grow adjacent to blood vessels in normal brain tissue, tumor cells …
While invasive tumor cells grow adjacent to blood vessels in normal brain tissue, tumor cells …
Long-term treatment with valganciclovir improves lentiviral suicide gene therapy of glioblastoma
Background Suicide gene therapy for malignant gliomas has shown encouraging results in
the latest clinical trials. However, prodrug application was most often restricted to short-term …
the latest clinical trials. However, prodrug application was most often restricted to short-term …
Analysis of the growth dynamics of angiogenesis-dependent and-independent experimental glioblastomas by multimodal small-animal PET and MRI
T Viel, KM Talasila, P Monfared, J Wang… - Journal of Nuclear …, 2012 - Soc Nuclear Med
The hypothesis of this study was that distinct experimental glioblastoma phenotypes
resembling human disease can be noninvasively distinguished at various disease stages by …
resembling human disease can be noninvasively distinguished at various disease stages by …
[PDF][PDF] Expansive growth of two glioblastoma stem-like cell lines is mediated by bFGF and not by EGF
…, B Radlwimmer, C Herold-Mende, KM Talasila… - Radiology and …, 2013 - sciendo.com
Background. Patient-derived glioblastoma (GBM) stem-like cells (GSCs) represent a
valuable model for basic and therapeutic research. GSCs are usually propagated in serum-free …
valuable model for basic and therapeutic research. GSCs are usually propagated in serum-free …
Cathepsin L silencing enhances arsenic trioxide mediated in vitro cytotoxicity and apoptosis in glioblastoma U87MG spheroids
M Primon, PC Huszthy, H Motaln, KM Talasila… - Experimental cell …, 2013 - Elsevier
Despite improved treatment options, glioblastoma multiforme (GBM) remains the most
aggressive brain tumour with the shortest post-diagnostic survival. Arsenite (As 2 O 3 ) is already …
aggressive brain tumour with the shortest post-diagnostic survival. Arsenite (As 2 O 3 ) is already …
[HTML][HTML] Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts
…, M Johannessen, SS Mitra, HK Jacobsen, KM Talasila… - BMC cancer, 2017 - Springer
Background Little is known about the role of glial host cells in brain tumours. However,
supporting stromal cells have been shown to foster tumour growth in other cancers. Methods We …
supporting stromal cells have been shown to foster tumour growth in other cancers. Methods We …
[HTML][HTML] Tumor versus stromal cells in culture—survival of the fittest?
KM Talasila, N Brekka, K Mangseth, D Stieber… - PloS one, 2013 - journals.plos.org
Two of the signature genetic events that occur in human gliomas, EGFR amplification and
IDH mutation, are poorly represented in experimental models in vitro. EGFR amplification, for …
IDH mutation, are poorly represented in experimental models in vitro. EGFR amplification, for …
Cathepsin L silencing increases As2O3 toxicity in malignantly transformed pilocytic astrocytoma MPA58 cells by activating caspases 3/7
M Primon, PC Huszthy, H Motaln, KM Talasila… - Experimental Cell …, 2017 - Elsevier
Low-grade, pilocytic astrocytomas are treated by resection, but additional therapy is necessary
for those tumors with anaplastic features. Arsenic trioxide (As 2 O 3 ) is emerging as an …
for those tumors with anaplastic features. Arsenic trioxide (As 2 O 3 ) is emerging as an …