PTEN (phosphatase and tensin homolog) loss of function is the most common genetic
aberration in endometrioid endometrial carcinomas. In addition to its well-described role in cell …

Endometrial cancer comprises a heterogeneous group of tumors, with distinct risk factors,
clinical presentation, histopathological features and molecular characteristics. Currently, …

Objective To determine whether risk adapted intraoperative radiotherapy, delivered as a
single dose during lumpectomy, can effectively replace postoperative whole breast external …

Utilizing the concept of synthetic lethality has provided new opportunities for the development
of targeted therapies, by allowing the targeting of loss of function genetic aberrations. In …

Endometriosis is a common gynecological disease affecting 6%–10% of women of reproductive
age and is characterized by the presence of endometrial-like tissue in localizations …

Down-regulation of Drosha and Dicer has been suggested to be of prognostic value in some
cancers. The aims of our study were to investigate the down-regulation of Drosha and Dicer …

ARID1A mutations are observed in various tumors, including ovarian clear cell (OCCC) and
endometrioid carcinomas, endometrial, and breast carcinomas. They commonly result in …

Background. A 58-year-old woman presented with metastatic endometrioid endometrial
adenocarcinoma after being previously treated with surgery and adjuvant radiotherapy for early-…

Micropapillary carcinoma ( MPC ) is a rare histological special type of breast cancer, characterized
by an aggressive clinical behaviour and a pattern of copy number aberrations ( CNAs …

Importance Conventional adjuvant radiotherapy for breast cancer given daily for several
weeks is onerous and expensive. Some patients may be obliged to choose a mastectomy …