Development of a long-acting injectable formulation with nanoparticles of rilpivirine (TMC278) for HIV treatment
…, M François, A Wouters, E Basstanie, K Iterbeke… - European Journal of …, 2009 - Elsevier
Long-acting parenteral formulations of antiretrovirals could facilitate maintenance and
prophylactic treatment in HIV. Using the poorly water- and oil-soluble non-nucleoside reverse …
prophylactic treatment in HIV. Using the poorly water- and oil-soluble non-nucleoside reverse …
[PDF][PDF] Organometallic 99mTc-aquaion labels peptide to an unprecedented high specific activity
…, D Tourwé, L Jeannin, K Iterbeke… - Journal of Nuclear …, 1999 - Soc Nuclear Med
A new peptide labeling method that uses the Organometallic aquaion [99rnTc (H2O) 3 (CO)
3]+ has been developed. Methods: A selection of amino acids was labeled at different …
3]+ has been developed. Methods: A selection of amino acids was labeled at different …
Pharmacokinetics of darunavir in fixed‐dose combination with cobicistat compared with coadministration of darunavir and ritonavir as single agents in healthy …
…, M Opsomer, M Timmers, K Iterbeke… - The Journal of …, 2014 - Wiley Online Library
This study compared the bioavailability of two candidate fixed‐dose combinations (FDCs:
G003 and G004) of darunavir/cobicistat 800/150 mg with that of darunavir 800 mg and ritonavir …
G003 and G004) of darunavir/cobicistat 800/150 mg with that of darunavir 800 mg and ritonavir …
In vitro and in vivo evaluation of new radiolabeled neurotensin (8–13) analogues with high affinity for NT1 receptors
…, N Carrel-Rémy, D Tourwé, K Iterbeke… - Nuclear medicine and …, 2001 - Elsevier
The potential utility of neurotensin (NT) in cancer diagnosis and therapy is limited by its
rapid degradation. New stabilized analogues were synthesized, labeled with [ 99m Tc] and …
rapid degradation. New stabilized analogues were synthesized, labeled with [ 99m Tc] and …
Preclinical evaluation of a new, stabilized neurotensin (8–13) pseudopeptide radiolabeled with 99mTc
…, M Bruehlmeier, A Blanc, K Iterbeke… - Journal of Nuclear …, 2002 - Soc Nuclear Med
The rapid degradation of neurotensin (NT) limits its clinical use in cancer imaging and therapy.
Thus, a new NT(8–13) pseudopeptide, NT-VIII, was synthesized. Some changes were …
Thus, a new NT(8–13) pseudopeptide, NT-VIII, was synthesized. Some changes were …
Biodistribution and catabolism of 18F-labeled neurotensin (8–13) analogs
…, M Kretzschmar, H Rodig, D Tourwé, K Iterbeke… - Nuclear medicine and …, 2002 - Elsevier
4-([ 18 F]fluoro)benzoyl-neurotensin(8–13) ( 18 FB-Arg 8 -Arg 9 -Pro 10 -Tyr 11 - Ile 12 -Leu
13 -OH, 1) and two analogs stabilized in one and two positions ( 18 FB-Arg 8 ψ(CH 2 NH)…
13 -OH, 1) and two analogs stabilized in one and two positions ( 18 FB-Arg 8 ψ(CH 2 NH)…
Darunavir/cobicistat once daily for the treatment of HIV
…, S Vanveggel, K Iterbeke… - Expert review of anti …, 2015 - Taylor & Francis
A current focus in HIV management is improving adherence by minimizing pill burden with
convenient formulations, including fixed-dose combinations (FDCs). Darunavir, a HIV …
convenient formulations, including fixed-dose combinations (FDCs). Darunavir, a HIV …
Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition
…, G Elaut, V Brecx, P Papeleu, K Iterbeke… - Bioorganic & medicinal …, 2003 - Elsevier
The synthesis of new amide type histone deacetylase inhibitors is described, having an (R)-methyl
substituent and a diene or saturated structure of the chain linking the hydroxamic acid …
substituent and a diene or saturated structure of the chain linking the hydroxamic acid …
Efficient Synthesis of (S)-4-Phthalimido-1,3,4,5- tetrahydro-8-(2,6-dichlorobenzyloxy)-3-oxo-2H-2-benzazepin-2-acetic Acid (Pht-Hba(2,6-Cl2-Bn)-Gly-OH)1
JR Casimir, D Tourwe, K Iterbeke… - The Journal of …, 2000 - ACS Publications
4-Amino-2-benzazepin-3-ones have proven very useful for studying the biologically active
conformations of peptides. The synthesis of Pht-Aba-Xaa-OH by reaction of the corresponding …
conformations of peptides. The synthesis of Pht-Aba-Xaa-OH by reaction of the corresponding …
Rhenium (Re) and technetium (Tc)‐99M oxocomplexes of neurotensin (8‐13)
…, D Terriere, J Mertens, K Iterbeke… - Journal of Labelled …, 1999 - Wiley Online Library
Radio‐labelled Neurotensin (NT) analogues have applications as potential tumour imaging
agents. In this study, the N 2 N′S chelator dimethylGly‐Ser‐Cys (acetomidomethyl)‐Gly (…
agents. In this study, the N 2 N′S chelator dimethylGly‐Ser‐Cys (acetomidomethyl)‐Gly (…