[HTML][HTML] Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes: results from a randomized clinical trial
JP Koffert, K Mikkola, KA Virtanen… - diabetes research and …, 2017 - Elsevier
Aims Metformin therapy is associated with diffuse intestinal 18 F-fluoro-deoxyglucose (FDG)
accumulation in clinical diagnostics using routine FDG-PET imaging. We aimed to study …
accumulation in clinical diagnostics using routine FDG-PET imaging. We aimed to study …
64Cu- and 68Ga-Labelled [Nle14,Lys40(Ahx-NODAGA)NH2]-Exendin-4 for Pancreatic Beta Cell Imaging in Rats
M Kirsi, Y Cheng-Bin, F Veronica, I Tamiko… - Molecular imaging and …, 2014 - Springer
Purpose Glucagon-like peptide-1 receptor (GLP-1R) is a molecular target for imaging of
pancreatic beta cells. We compared the ability of [Nle 14 ,Lys 40 (Ahx-NODAGA- 64 Cu)NH 2 ]-…
pancreatic beta cells. We compared the ability of [Nle 14 ,Lys 40 (Ahx-NODAGA- 64 Cu)NH 2 ]-…
Assessment of islet specificity of dihydrotetrabenazine radiotracer binding in rat pancreas and human pancreas
V Fagerholm, KK Mikkola, T Ishizu… - Journal of Nuclear …, 2010 - Soc Nuclear Med
Assessment of Islet Specificity of Dihydrotetrabenazine Radiotracer Binding in Rat Pancreas
and Human Pancreas | Journal of Nuclear Medicine Skip to main content Main menu Home …
and Human Pancreas | Journal of Nuclear Medicine Skip to main content Main menu Home …
The cannabinoid receptor-1 is an imaging biomarker of brown adipose tissue
O Eriksson, K Mikkola, D Espes… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Recently, the existence of significant deposits of brown adipose tissue (BAT) in human
adults was confirmed. Its role in the human metabolism is unknown but could be substantial. …
adults was confirmed. Its role in the human metabolism is unknown but could be substantial. …
Pancreatic metabolism, blood flow, and β-cell function in obese humans
…, P Salminen, M Soinio, K Mikkola… - The Journal of …, 2014 - academic.oup.com
Context: Glucolipotoxicity is believed to induce pancreatic β-cell dysfunction in obesity.
Previously, it has not been possible to study pancreatic metabolism and blood flow in humans. …
Previously, it has not been possible to study pancreatic metabolism and blood flow in humans. …
[HTML][HTML] Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body …
N Morrice, S Vainio, K Mikkola, L van Aalten… - Molecular …, 2023 - Elsevier
Objectives Metformin is the first line therapy recommended for type 2 diabetes. However,
the precise mechanism of action remains unclear and up to a quarter of patients show some …
the precise mechanism of action remains unclear and up to a quarter of patients show some …
[HTML][HTML] Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, 18F-labeled [Nle14,Lys40]exendin-4 analog, shows promise for clinical imaging
K Mikkola, CB Yim, P Lehtiniemi, S Kauhanen… - EJNMMI research, 2016 - Springer
Background Several radiometal-labeled, exendin-based tracers that target glucagon-like
peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main …
peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main …
Synthesis and preclinical characterization of [64Cu] NODAGA-MAL-exendin-4 with a Nε-maleoyl-l-lysyl-glycine linkage
CB Yim, K Mikkola, V Fagerholm, VV Elomaa… - Nuclear Medicine and …, 2013 - Elsevier
Introduction Renal localization of high radioactivity levels during targeted imaging compromises
tissue visualization in the kidney region and limits diagnostic accuracy. Radioiodinated …
tissue visualization in the kidney region and limits diagnostic accuracy. Radioiodinated …
68Ga-NODAGA-exendin-4 PET/CT for the localization of insulinomas
M Boss, K Mikkola, M Buitinga, M Brom… - Nuklearmedizin …, 2019 - thieme-connect.com
Insulinomas are usually small, single benign tumors. Precise preoperative anatomical
localization of the tumor is essential. Imaging techniques like CT, MRI as well as somatostatin …
localization of the tumor is essential. Imaging techniques like CT, MRI as well as somatostatin …
Erratum to:(64) Cu-and (68) Ga-Labelled [Nle (14), Lys (40)(Ahx-NODAGA) NH 2]-Exendin-4 for Pancreatic Beta Cell Imaging in Rats
K Mikkola, CB Yim, V Fagerholm, T Ishizu… - Molecular imaging and …, 2014 - boris.unibe.ch
BORIS Deutsch English Français Login BORIS Bern Open Repository and Information
System University of Bern Home Statistics Erratum to: (64)Cu- and (68)Ga-Labelled [Nle (14),Lys …
System University of Bern Home Statistics Erratum to: (64)Cu- and (68)Ga-Labelled [Nle (14),Lys …