In vivo SPECT quantification of transplanted cell survival after engraftment using 111In-tropolone in infarcted canine myocardium

KJ Blackwood, B Lewden, RG Wells… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Current investigations of cell transplant therapies in damaged myocardium are limited by
the inability to quantify cell transplant survival in vivo. We describe how the labeling of cells …

Can the inflammatory response be evaluated using 18F-FDG within zones of microvascular obstruction after myocardial infarction?

…, J Sykes, L Keenliside, KJ Blackwood… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Inflammation that occurs after acute myocardial infarction plays a pivotal role in healing by
facilitating the creation of a supportive scar. F-FDG, which is taken up avidly by macrophages, …

A method for quantitative cell tracking using SPECT for the evaluation of myocardial stem cell therapy

RZ Stodilka, KJ Blackwood, H Kong… - Nuclear medicine …, 2006 - journals.lww.com
Purpose A promising SPECT-based method for evaluating stem cells therapy uses 111 In-labelled
cells, transfected with a reporter gene. Cells are first transplanted to the infarct, and …

Hybrid SPECT/cardiac‐gated first‐pass perfusion CT: locating transplanted cells relative to infarcted myocardial targets

…, J White, KJ Blackwood, J Sykes… - Contrast media & …, 2012 - Wiley Online Library
Purpose A challenge with cardiac cell therapy is determining the location of cells relative to
infarct tissue. As cells are viable following 111 In‐labeling, and first‐pass CT imaging can …

[HTML][HTML] Comparison of the myocardial clearance of endothelial progenitor cells injected early versus late into reperfused or sustained occlusion myocardial infarction

…, E Sabondjian, KJ Blackwood, J Sykes… - … International Journal of …, 2013 - Springer
Stem cell transplantation following AMI has shown promise for the repair or reduction of the
amount of myocardial injury. There is some evidence that these treatment effects appear to …

[HTML][HTML] Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial

…, MW Carroll, J Ervin, MC Diehl, E Blackwood… - …, 2021 - thelancet.com
Background A vaccine against SARS-CoV-2 is of high urgency. Here the safety and
immunogenicity induced by a DNA vaccine (INO-4800) targeting the full length spike antigen of …

Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: a preliminary report of a randomized, blinded, placebo-controlled, Phase 2 clinical trial in …

…, J Agnes, M Giffear, KA Kraynyak, E Blackwood… - MedRxiv, 2021 - medrxiv.org
Background Vaccines against SARS-CoV-2 are still urgently needed as only 5% of the global
population has been vaccinated. Here we report the safety and immunogenicity of a DNA …

SARS-CoV-2 DNA vaccine INO-4800 induces durable immune responses capable of being boosted in a phase 1 open-label trial

KA Kraynyak, E Blackwood, J Agnes… - The Journal of …, 2022 - academic.oup.com
Background Additional severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines that are safe and effective as primary vaccines and boosters remain urgently needed …

[HTML][HTML] Comparison of 111In Leakage from Labeled Endocardial and Epicardial Cells: Impact on Modeling Viability of Cells to Be Transplanted into Myocardium

KJ Blackwood, J Sykes, L Deans… - International Journal of …, 2011 - hindawi.com
Introduction. Previously we proposed a cellular imaging technique to determine the surviving
fraction of transplanted cells in vivo. Epicardial kinetics using Indium-111 determined the …

[HTML][HTML] Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain

X Duan, JH Chang, S Ge, RL Faulkner, JY Kim… - Cell, 2007 - cell.com
Adult neurogenesis occurs throughout life in discrete regions of the adult mammalian brain.
Little is known about the mechanism governing the sequential developmental process that …