Importance Adult survivors of childhood cancer are known to be at risk for treatment-related
adverse health outcomes. A large population of survivors has not been evaluated using a …

Background Survivors of childhood cancer develop early and severe chronic health
conditions (CHCs). A quantitative landscape of morbidity of survivors, however, has not been …

Background Among patients in whom childhood cancer was diagnosed in the 1970s and
1980s, 18% of those who survived for 5 years died within the subsequent 25 years. In recent …

Background Adult survivors of childhood central nervous system (CNS) malignancies are at
high risk for long-term morbidity and late mortality. However, patterns of late mortality, the …

Background: No studies have estimated the population-level burden of morbidity in individuals
diagnosed with cancer as children (ages 0–19 years). We updated prevalence estimates …

Difficulties with negotiating and achieving desired social outcomes in life may be exacerbated
by the experience of childhood cancer, including adverse effects from therapies used to …

Purpose Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic
leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors …

… The glmulti function of R software (R Foundation for Statistical Computing, Vienna, Austria)
was used to select the best set of risk factors with minimum Akaike information criterion (AIC) …

Background : Treatment-related cardiac death is the primary, noncancer cause of mortality
in adult survivors of childhood malignancies. Early detection of cardiac dysfunction may …

Purpose Frailty, a phenotype reported among 9.9% of individuals 65 years old and older (9.6%
of women; 5.2% of men), has not been assessed among adult childhood cancer …