Human peripheral blood lymphocytes can be transduced to express antigen-dependent
CD3ζ chimeric immune receptors (CIRs), which function independently of the T-cell receptor (…

Worldwide, approximately 405 000 cases of oral cancer (OSCC) are diagnosed each year,
with a rising incidence in many countries. Despite advances in surgery and radiotherapy, …

The primary aim of this clinical trial was to determine the feasibility of delivering first-generation
CAR T cell therapy to patients with advanced, CEACAM5 + malignancy. Secondary aims …

Although recent methods for the engineering of antibody–drug conjugates (ADCs) have gone
some way to addressing the challenging issues of ADC construction, significant hurdles …

Introduction: There is a great unmet need for effective new treatments in cancer, which
continues to be a major cause of death. Antibody–drug conjugates (ADCs) are emerging, after a …

The advent of Adcetris™ and Kadcyla™, two recently FDA-approved antibody–drug conjugates
(ADCs), in the clinic has had a major impact on the treatment of lymphoma and breast …

Insertion of antibody genes into filamentous bacteriophage makes it possible to generate
and screen libraries of 10 7 or more antibodies. Each phage expresses an antibody on its …

The magnetic properties and safety of dextran-coated superparamagnetic iron oxide
nanoparticles (SPIONs) have facilitated their clinical use as MRI contrast agents and stimulated …

Surgery is the cornerstone of oncologic therapy with curative intent. However, identification of
tumor cells in the resection margins is difficult, resulting in nonradical resections, increased …

In this communication we describe a novel acid-cleavable linker strategy for antibody–drug
conjugation. Functional disulfide bridging of the single interchain disulfide bond of a …