Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain
barrier (BBB). Here, we report the engineering and characterization of a BBB transport …

Neuroinflammation is a hallmark of ischemic stroke, which is a leading cause of death and
long‐term disability. Understanding the exact cellular signaling pathways that initiate and …

Background Ischemic stroke provokes a neuroinflammatory response and simultaneously
promotes release of epinephrine and norepinephrine by the sympathetic nervous system. This …

Neuroinflammation plays a key role in neuronal injury after ischemic stroke. PET imaging of
translocator protein 18 kDa (TSPO) permits longitudinal, noninvasive visualization of …

Rationale: Localized blood-brain barrier (BBB) opening can be achieved with minimal to no
tissue damage by applying pulsed focused ultrasound alongside a low microbubble (MB) …

Background B cells play a central role in multiple sclerosis (MS) through production of
injurious antibodies, secretion of pro-inflammatory cytokines, and antigen presentation. The …

Obesity is associated with chronic peripheral inflammation, is a risk factor for stroke, and causes
increased infarct sizes. To characterize how obesity increases infarct size, we fed a high-…

Neuroinflammation plays a key role in neuronal injury following ischemic stroke. Positron
emission tomography (PET) imaging of translocator protein 18 kDa (TSPO) permits longitudinal…

Stroke is a cerebrovascular event resulting in cell death in the brain, neurological deficits,
and other complications. Stroke is one of the most common causes of death and disability …

Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease
(AD), suggesting that activation of this innate immune receptor may be a useful therapeutic …