UV-associated mutations underlie the etiology of MCV-negative Merkel cell carcinomas
Merkel cell carcinoma (MCC) is an uncommon, but highly malignant, cutaneous tumor. Merkel
cell polyoma virus (MCV) has been implicated in a majority of MCC tumors; however, viral-…
cell polyoma virus (MCV) has been implicated in a majority of MCC tumors; however, viral-…
Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell …
RJ Young, K Waldeck, C Martin, JH Foo… - Pigment cell & …, 2014 - Wiley Online Library
We have investigated the potential for the p16‐cyclin D‐ CDK 4/6‐retinoblastoma protein
pathway to be exploited as a therapeutic target in melanoma. In a cohort of 143 patients with …
pathway to be exploited as a therapeutic target in melanoma. In a cohort of 143 patients with …
The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast …
Breast cancer metastasis to the bone occurs frequently, causing numerous complications
including severe pain, fracture, hypercalcemia, and paralysis. Despite its prevalence and …
including severe pain, fracture, hypercalcemia, and paralysis. Despite its prevalence and …
[HTML][HTML] Enhancing the anti-tumour activity of 177Lu-DOTA-octreotate radionuclide therapy in somatostatin receptor-2 expressing tumour models by targeting PARP
C Cullinane, K Waldeck, L Kirby, BE Rogers, P Eu… - Scientific reports, 2020 - nature.com
Peptide receptor radionuclide therapy (PRRT) is an important treatment option for patients
with somatostatin receptor-2 (SSTR2)-expressing neuroendocrine tumour (NET) though …
with somatostatin receptor-2 (SSTR2)-expressing neuroendocrine tumour (NET) though …
Relationship between Epidermal Growth Factor Receptor Status, p16INK4A, and Outcome in Head and Neck Squamous Cell Carcinoma
Background: Human papilloma virus (HPV) infection is a powerful prognostic biomarker in
head and neck squamous cell carcinoma (HNSCC). Increased epidermal growth factor …
head and neck squamous cell carcinoma (HNSCC). Increased epidermal growth factor …
The genomic landscape of phaeochromocytoma
…, P James, A Hogg, K Waldeck… - The Journal of …, 2015 - Wiley Online Library
Phaeochromocytomas ( PCCs ) and paragangliomas ( PGLs ) are rare neural crest‐derived
tumours originating from adrenal chromaffin cells or extra‐adrenal sympathetic and …
tumours originating from adrenal chromaffin cells or extra‐adrenal sympathetic and …
Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance
…, S Abuhammad, EJ Lelliott, K Waldeck… - … Journal of Cancer, 2018 - Wiley Online Library
Increased CDK4 activity occurs in the majority of melanomas and CDK4/6 inhibitors in
combination with BRAF and MEK inhibitors are currently in clinical trials for the treatment of …
combination with BRAF and MEK inhibitors are currently in clinical trials for the treatment of …
A Bivalent Inhibitor of Prostate Specific Membrane Antigen Radiolabeled with Copper‐64 with High Tumor Uptake and Retention
…, JK Van Zuylekom, K Waldeck… - Angewandte Chemie …, 2019 - Wiley Online Library
Molecules containing lysine‐ureido‐glutamate functional groups bind to the active site of
prostate specific membrane antigen, which is overexpressed in prostate cancer. To prepare …
prostate specific membrane antigen, which is overexpressed in prostate cancer. To prepare …
The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ-Myc Lymphoma by Restoring Oncogene-Induced Senescence
…, MJ Bywater, KM Kinross, MV Astle, K Waldeck… - Cancer discovery, 2013 - AACR
MYC deregulation is common in human cancer. IG-MYC translocations that are modeled in
Eμ-Myc mice occur in almost all cases of Burkitt lymphoma as well as in other B-cell …
Eμ-Myc mice occur in almost all cases of Burkitt lymphoma as well as in other B-cell …
γδ T cells in merkel cell carcinomas have a proinflammatory profile prognostic of patient survival
NA Gherardin, K Waldeck, A Caneborg… - Cancer immunology …, 2021 - AACR
Merkel cell carcinomas (MCC) are immunogenic skin cancers associated with viral infection
or UV mutagenesis. To study T-cell infiltrates in MCC, we analyzed 58 MCC lesions from 39 …
or UV mutagenesis. To study T-cell infiltrates in MCC, we analyzed 58 MCC lesions from 39 …