miR-193b–Regulated Signaling Networks Serve as Tumor Suppressors in Liposarcoma and Promote Adipogenesis in Adipose-Derived Stem Cells
Well-differentiated and dedifferentiated liposarcomas (WDLS/DDLS) account for approximately
13% of all soft tissue sarcoma in adults and cause substantial morbidity or mortality in the …
13% of all soft tissue sarcoma in adults and cause substantial morbidity or mortality in the …
[HTML][HTML] Tunneling nanotubes: an alternate route for propagation of the bystander effect following oncolytic viral infection
J Ady, V Thayanithy, K Mojica, P Wong, J Carson… - Molecular Therapy …, 2016 - cell.com
Tunneling nanotubes (TNTs) are ultrafine, filamentous actin-based cytoplasmic extensions
which form spontaneously to connect cells at short and long-range distances. We have …
which form spontaneously to connect cells at short and long-range distances. We have …
[HTML][HTML] A novel oncolytic viral therapy and imaging technique for gastric cancer using a genetically engineered vaccinia virus carrying the human sodium iodide …
Background Gastric cancers have poor overall survival despite recent advancements in
early detection methods, endoscopic resection techniques, and chemotherapy treatments. …
early detection methods, endoscopic resection techniques, and chemotherapy treatments. …
An oncolytic vaccinia virus expressing the human sodium iodine symporter prolongs survival and facilitates SPECT/CT imaging in an orthotopic model of malignant …
Background The purpose of this work was to examine the ability of an oncolytic vaccinia virus
expressing the human sodium iodine transporter (hNIS) to provide real time monitoring of …
expressing the human sodium iodine transporter (hNIS) to provide real time monitoring of …
A vaccinia virus encoding the human sodium iodide symporter facilitates long-term image monitoring of virotherapy and targeted radiotherapy of pancreatic cancer
To assess therapeutic response and potential toxicity of oncolytic virotherapy, a noninvasive,
deep-tissue imaging modality is needed. This study aimed to assess the feasibility, …
deep-tissue imaging modality is needed. This study aimed to assess the feasibility, …
[HTML][HTML] Recombinant vaccinia virus GLV-1h68 is a promising oncolytic vector in the treatment of cholangiocarcinoma
A Pugalenthi, K Mojica, JW Ady, C Johnsen… - Cancer gene …, 2015 - nature.com
Although early stage cholangiocarcinoma (CC) can be cured by surgical extirpation, the
options for treatment of advanced stage CC are very few and suboptimal. Oncolytic virotherapy …
options for treatment of advanced stage CC are very few and suboptimal. Oncolytic virotherapy …
Oncolytic immunotherapy using recombinant vaccinia virus GLV-1h68 kills sorafenib-resistant hepatocellular carcinoma efficiently
JW Ady, J Heffner, K Mojica, C Johnsen, LJ Belin… - Surgery, 2014 - Elsevier
Background Sorafenib is the standard systemic therapy for unresectable or recurrent
hepatocellular carcinoma (HCC) but adds minimal increase in survival. Therefore, there is a great …
hepatocellular carcinoma (HCC) but adds minimal increase in survival. Therefore, there is a great …
Oncolytic gene therapy with recombinant vaccinia strain GLV-2b372 efficiently kills hepatocellular carcinoma
JW Ady, C Johnsen, K Mojica, J Heffner, D Love… - Surgery, 2015 - Elsevier
Background Hepatocellular carcinoma (HCC) commonly presents at a late stage when surgery
is no longer a curative option. As such, novel therapies for advanced HCC are needed. …
is no longer a curative option. As such, novel therapies for advanced HCC are needed. …
Irreversible electroporation ablation of the liver can be detected with ultrasound B-mode and elastography
BACKGROUND: Irreversible electroporation (IRE) is a novel ablation technique that induces
permanent membrane permeability and cell death. We are interested in ultrasound B-mode …
permanent membrane permeability and cell death. We are interested in ultrasound B-mode …
Gene therapy using therapeutic and diagnostic recombinant oncolytic vaccinia virus GLV-1h153 for management of colorectal peritoneal carcinomatosis
C Eveno, K Mojica, JW Ady, DLJ Thorek, V Longo… - Surgery, 2015 - Elsevier
Background Peritoneal carcinomatosis (PC) is a terminal progression of colorectal cancer (CRC).
Poor response to cytoreductive operation and chemotherapy coupled with the inability …
Poor response to cytoreductive operation and chemotherapy coupled with the inability …