Research leading to the discovery of a series of mutagenic and carcinogenic heterocyclic
amines (HCAs) was inspired by the idea that smoke produced during cooking of food, …

A review of the literature on the mutagenicity/genotoxicity of surface waters is presented in
this article. Subheadings of this article include a description of sample concentration methods, …

Cooked food contains a variety of mutagenic heterocyclic amines. All the mutagenic heterocyclic
amines tested were carcinogenic in rodents when given in the diet at 0.01–0.08%. Most …

Accumulating evidence indicates that overproduction of prostanoids attributable to
overexpression of cyclooxygenase-2 (COX-2) plays an important role in colon carcinogenesis. We …

Prostate tissues obtained from rats given a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
(PhIP), at a dose of 400 ppm in the diet for 52 weeks were …

Although the cyclooxygenase pathway of the arachidonic acid cascade has been suggested
to play an important role in colon carcinogenesis, the molecular species of prostanoids and …

Studies of colon carcinogenesis in animal models are very useful to elucidate mechanisms
and provide pointers to potential prevention approaches in the human situation. In the rat …

Cyclooxygenase-2 (COX-2) is abundantly expressed in colon cancer cells. It has been reported
that inhibition of COX-2 enzyme activity is shown to prevent colon carcinogenesis. Thus, …

Although an accumulating body of evidence indicates that levels of prostaglandin E 2 (PGE
2 ) in human and rodent colon cancers are higher than those in surrounding normal tissues, …

The mouse model for familial adenomatous polyposis, Apc Min/+ mouse, contains a truncating
mutation in the Apc gene and spontaneously develops numerous adenomas in the small …