Pitavastatin, a novel potent 3-hydroxymethylglutaryl-CoA reductase inhibitor, is selectively
distributed to the liver in rats. However, the hepatic uptake mechanism of pitavastatin has not …

Organic anion transporting polypeptide (OATP) family transporters accept a number of
drugs and are increasingly being recognized as important factors in governing drug and …

Rosuvastatin is an HMG-CoA reductase inhibitor and one of the most hydrophilic among the
commercially available statins. It is efficiently accumulated in the liver and excreted into the …

Hepatobiliary excretion mediated by transporters, organic anion-transporting polypeptide (OATP)
1B1 and multidrug resistance-associated protein (MRP) 2, is the major elimination …

It has already been demonstrated that pitavastatin, a novel potent HMG-coenzyme A
reductase inhibitor, is taken up into human hepatocytes mainly by organic anion transporting …

Pitavastatin, a novel potent 3-hydroxymethylglutaryl coenzyme A reductase inhibitor, is
distributed selectively to the liver and excreted into bile in unchanged form in rats. We reported …

Elucidation of the rate-determining process in the overall hepatic elimination of drugs is critical
for predicting their intrinsic hepatic clearance and the impact of variation of sequestration …

Valsartan is a highly selective angiotensin II AT1-receptor antagonist for the treatment of
hypertension. Valsartan is mainly excreted into the bile in unchanged form. Because valsartan …

Objective Recent reports have shown that genetic polymorphisms in organic anion transporting
polypeptide (OATP) 1B1 have an effect on the pharmacokinetics of drugs. However, the …

Pravastatin is a well known 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor. Cumulative
studies have shown that pravastatin is taken up into hepatocytes by the organic anion …