'Ischemic tolerance'phenomenon found in the brain

K Kitagawa, M Matsumoto, M Tagaya, R Hata, H Ueda… - Brain research, 1990 - Elsevier
We investigated the possibility that neuronal cells given a mild ischemic treatment sufficient
to perturb the cellular metabolism acquired tolerance to a subsequent, and what would be …

Common carotid intima-media thickness measurements in cardiovascular risk prediction: a meta-analysis

…, S Holewijn, A Ikeda, M Kavousi, K Kitagawa… - Jama, 2012 - jamanetwork.com
Context The evidence that measurement of the common carotid intima-media thickness (CIMT)
improves the risk scores in prediction of the absolute risk of cardiovascular events is …

The effect of crosslinking on the mechanical properties of polylactic acid/polycaprolactone blends

T Semba, K Kitagawa, US Ishiaku… - Journal of applied …, 2006 - Wiley Online Library
The improvement of the brittle behavior of Polylactic acid (PLA) resin was studied by blending
it with Polycaprolactone (PCL) resin. These materials were fabricated into the compressed …

'Ischemic tolerance'phenomenon detected in various brain regions

K Kitagawa, M Matsumoto, K Kuwabara, M Tagaya… - Brain research, 1991 - Elsevier
We investigated the effects of mild and non-lethal ischemic insult on neuronal death
following subsequent lethal ischemic stress in various brain regions, using a gerbil model of …

Neurogenesis by progenitor cells in the ischemic adult rat hippocampus

Y Yagita, K Kitagawa, T Ohtsuki, K Takasawa, T Miyata… - Stroke, 2001 - Am Heart Assoc
Background and Purpose— Recently, there has been great interest in adult neurogenesis.
We investigated whether transient forebrain ischemia could influence the proliferation of …

C-reactive protein is an independent predictor of the rate of increase in early carotid atherosclerosis

H Hashimoto, K Kitagawa, H Hougaku, Y Shimizu… - Circulation, 2001 - Am Heart Assoc
Background—An elevated plasma concentration of high-sensitivity C-reactive protein (hs-CRP)
is a strong predictor of cardiovascular events. However, there have been no longitudinal …

Contribution of microglia/macrophages to expansion of infarction and response of oligodendrocytes after focal cerebral ischemia in rats

T Mabuchi, K Kitagawa, T Ohtsuki, K Kuwabara… - Stroke, 2000 - Am Heart Assoc
Background and Purpose—The purpose of this study was (1) to examine the contribution of
microglia and macrophages with their interleukin-1β production and (2) to assess the …

Efficacy and safety of adjusted-dose prasugrel compared with clopidogrel in Japanese patients with acute coronary syndrome–the PRASFIT-ACS study–

…, H Yokoi, S Nanto, M Takayama, K Kitagawa… - Circulation …, 2014 - jstage.jst.go.jp
Background: Prasugrel is an antiplatelet agent that shows more prompt, potent, and consistent
platelet inhibition than clopidogrel. The objective of this study was to confirm the efficacy …

Phosphorylation of cAMP response element-binding protein in hippocampal neurons as a protective response after exposure to glutamate in vitro and ischemia in vivo

T Mabuchi, K Kitagawa, K Kuwabara… - Journal of …, 2001 - Soc Neuroscience
Although accumulating evidence indicates that cAMP response element-binding protein (CREB)
phosphorylation mediates not only synaptic plasticity but also survival of certain neurons…

Cerebral ischemia after bilateral carotid artery occlusion and intraluminal suture occlusion in mice: evaluation of the patency of the posterior communicating artery

K Kitagawa, M Matsumoto, G Yang… - Journal of Cerebral …, 1998 - journals.sagepub.com
Cerebral ischemia models using mice have drawn increasing attention, particularly because
of the availability of transgenic animals. However, the variability of intracranial vasculature …