Effects of non-steroidal anti-inflammatory drugs on Aβ deposition in Aβ1–42 transgenic C. elegans

M Morita, K Osoda, M Yamazaki, F Shirai, N Matsuoka… - Brain research, 2009 - Elsevier
Although epidemiological studies have shown that long-term treatment with non-steroidal
anti-inflammatory drugs (NSAIDs) may protect against Alzheimer's disease (AD), the …

Pharmacokinetic animal PET study of FK506 as a potent neuroprotective agent

…, H Takamatsu, A Noda, K Osoda… - Journal of Nuclear …, 2004 - Soc Nuclear Med
The immunosuppressive agent FK506 (tacrolimus) has neuroprotective properties not only
in rodents but also in nonhuman primates. To improve the accuracy of clinical studies of …

Boron Compound as a Trapping Reagent of. ALPHA.-Hydroxy o-Quinodimethanes in the Diels-Alder Reaction.

S Shimada, K Osoda, K Narasaka - Bulletin of the Chemical Society of …, 1993 - jlc.jst.go.jp
The Diels–Alder reaction of methyl 4-hydroxy-2-butenoate and α-hydroxy o-quinodimethanes,
generated from 1,2-dihydrobenzocyclobuten-1-ol derivatives by thermolysis, proceeds by …

Rapid synthesis of 11C-labeled FK506 for positron emission tomography

Y Murakami, A Kuroda, K Osoda, S Nishimura - Tetrahedron letters, 2003 - Elsevier
The present study describes a rapid synthesis method for labeled [ 11 C]FK506 for positron
emission tomography (PET). A one-pot reaction from [ 11 C]CH 3 I, involving a Wittig reaction …

Anionic polymerization of an acrylonitrile trimer studied by photoelectron spectroscopy

…, A Terasaki, T Kondow, K Osoda… - The Journal of …, 2001 - ACS Publications
A photoelectron spectrum of an acrylonitrile (AN:CH 2 CHCN) trimer anion, (AN) 3 - , produced
by electron impact on an acrylonitrile cluster was measured, and was compared with that …

Synthesis and evaluation of [11C]RU40555, a selective glucocorticoid receptor antagonist

…, Y Murakami, A Noda, K Osoda… - Journal of Labelled …, 2005 - Wiley Online Library
We demonstrated the synthesis of carbon‐11 labeled 17‐α‐hydroxy‐11‐β‐/4‐/[methyl]‐[1‐methylethyl]‐aminophenyl/‐17α‐[prop‐1‐ynyl]esta‐4‐9‐diene‐3‐one
(RU40555), a selective …

Substituent Effect of 1, 4-Benzenedicarbonitriles as Sensitizers on the Photoinduced Electron Transfer Reactions in Alcohol.

M Suzuki, T Ikeno, K Osoda, K Narasaka… - Bulletin of the Chemical …, 1997 - jlc.jst.go.jp
In the photosensitized electron transfer reaction of 6,6-diphenyl-1,4-dioxaspiro[4.5]decane
in methanol (MeOH), the quantum yield is increased by the use of 2-methylbenzene-1,4-…

PET measurement of FK506 concentration in a monkey model of stroke

Y Murakami, H Takamatsu, A Noda, K Osoda… - Nuclear medicine and …, 2007 - Elsevier
INTRODUCTION: The immunosuppressive agent FK506 (tacrolimus) has neuroprotective
properties in an experimental model of cerebral ischemia. To improve the accuracy of clinical …

[CITATION][C] Phenylboronic acid as a template in the Diels-Alder reaction

K Narasaka, S Shimada, K Osoda, N Iwasawa - Synthesis, 1991 - thieme-connect.com
Thieme E-Journals - Synthesis / Abstract DE EN Home Products Journals Books Book Series
Service Library Service Help Contact Portal SYNTHESIS Full-text search Full-text search Author …

Preparation of 1, 4-dicyanobenzene derivatives and the substituent effect of the sensitizers on photoinduced electron-transfer reactions

K Osoda, X Pannecoucke, K Narasaka - Chemistry letters, 1995 - academic.oup.com
Substituted 1,4-dicyanobenzenes are prepared as electron-accepting photosensitizers. The
efficiency of some photosensitized reactions is influenced remarkably by the substituent(s) …