We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of
radioiodine in neuroblastoma tumors after systemic nonviral polyplex-mediated sodium iodide …

Due to its dual role as reporter and therapy gene, the sodium iodide symporter (NIS) allows
noninvasive imaging of functional NIS expression by 123 I-scintigraphy or 124 I-PET imaging …

Currently, major limitations for the clinical application of adenovirus-mediated gene therapy
are high prevalence of neutralizing antibodies, widespread expression of the coxsackie-…

We recently demonstrated tumor-selective iodide uptake and therapeutic efficacy of combined
radiovirotherapy after systemic delivery of the theranostic sodium iodide symporter (NIS) …

Purpose: We recently reported the significant therapeutic efficacy of radioiodine therapy in
various tumor mouse models following transcriptionally targeted sodium iodide symporter (NIS…

The theranostic sodium iodide symporter (NIS) gene allows detailed molecular imaging of
transgene expression and application of therapeutic radionuclides. As a crucial step towards …

We reported the therapeutic efficacy of 131 I in hepatocellular carcinoma (HCC) cells stably
expressing the sodium iodide symporter (NIS) under the control of the tumor-specific α-…

We reported the induction of tumor-selective iodide uptake and therapeutic efficacy of 131 I
in a hepatocellular carcinoma (HCC) xenograft mouse model, using novel polyplexes based …

Background Nonviral polymer‐based gene transfer represents an adaptable system for
tumor‐targeted gene therapy because various design strategies of shuttle systems, together with …

Background: Anaplastic thyroid carcinoma (ATC), the most aggressive form of thyroid cancer,
is unresponsive to radioiodine therapy. The current study aimed to extend the diagnostic …