Domestic dog breeds exhibit remarkable morphological variations that result from centuries
of artificial selection and breeding. Identifying the genetic changes that contribute to these …

Gaucher disease is a lysosomal storage disorder caused by insufficient glucocerebrosidase
activity. Its hallmark manifestations are attributed to infiltration and inflammation by …

Background B cells play a central role in multiple sclerosis (MS) through production of
injurious antibodies, secretion of pro-inflammatory cytokines, and antigen presentation. The …

Canine neuroaxonal dystrophy (NAD) is a recessive, degenerative neurological disease of
young adult Rottweiler dogs (Canis lupus familiaris) characterized pathologically by axonal …

Genomic information could be used efficiently to improve traits that are expensive to
measure, sex limited or expressed late in life. This study analyzed the phenotypic variation …

199 Objectives: Although multiple disease-modifying immunomodulatory therapies are
available for relapsing-remitting multiple sclerosis (RR-MS) 1 , therapeutic selection and …

Alzheimer's disease (AD) is a pervasive, relentlessly progressive neurodegenerative
disorder that includes both hereditary and sporadic forms linked by common underlying …

Background: Transactive Response DNA Binding Protein 43 kDa (TDP-43) pathology is
frequently found in cases with Alzheimer’s disease (AD). TDP-43 pathology is associated with …

In 1984, the National Institute on Aging developed the Alzheimer's disease centers program.
The main goal of these centers is to advance the understanding of Alzheimer's disease and …

Parkinson’s disease (PD) is associated with aberrant innate immune responses, including
microglial activation and infiltration of peripheral myeloid cells into the central nervous system …