Phase I/II Study of Oncolytic HSVGM-CSF in Combination with Radiotherapy and Cisplatin in Untreated Stage III/IV Squamous Cell Cancer of the Head and Neck
…, K Thway, A Sibtain, IA McNeish, KL Newbold… - Clinical cancer …, 2010 - AACR
Purpose: This study sought to define the recommended dose of JS1/34.5-/47-/GM-CSF, an
oncolytic herpes simplex type-1 virus (HSV-1) encoding human granulocyte-macrophage …
oncolytic herpes simplex type-1 virus (HSV-1) encoding human granulocyte-macrophage …
Effect of age on the efficacy and safety of lenvatinib in radioiodine-refractory differentiated thyroid cancer in the phase III SELECT trial
MS Brose, FP Worden, KL Newbold, M Guo… - Journal of Clinical …, 2017 - ascopubs.org
Purpose In the Study of (E7080) Lenvatinib in Differentiated Cancer of the Thyroid (SELECT),
lenvatinib significantly prolonged progression-free survival (PFS) versus placebo in …
lenvatinib significantly prolonged progression-free survival (PFS) versus placebo in …
[HTML][HTML] Normal tissue complication probability (NTCP) modelling using spatial dose metrics and machine learning methods for severe acute oral mucositis resulting …
…, LC Welsh, AB Jones, U Schick, KL Newbold… - Radiotherapy and …, 2016 - Elsevier
Background and purpose Severe acute mucositis commonly results from head and neck (chemo)radiotherapy.
A predictive model of mucositis could guide clinical decision-making and …
A predictive model of mucositis could guide clinical decision-making and …
Radiosensitization by the ATR inhibitor AZD6738 through generation of acentric micronuclei
…, M Pedersen, H Hafsi, SA Bhide, KL Newbold… - Molecular cancer …, 2017 - AACR
AZD6738 is an orally active ATR inhibitor (ATRi) currently in phase I clinical trials. We found
in vitro growth inhibitory activity of this ATRi in a panel of human cancer cell lines. We …
in vitro growth inhibitory activity of this ATRi in a panel of human cancer cell lines. We …
[HTML][HTML] DARS: a phase III randomised multicentre study of dysphagia-optimised intensity-modulated radiotherapy (Do-IMRT) versus standard intensity-modulated …
…, E Miles, M Beasley, T Roques, SA Bhide, KL Newbold… - BMC cancer, 2016 - Springer
Background Persistent dysphagia following primary chemoradiation (CRT) for head and neck
cancers can have a devastating impact on patients’ quality of life. Single arm studies have …
cancers can have a devastating impact on patients’ quality of life. Single arm studies have …
Assessment and management of dysphagia in patients with head and neck cancer who receive radiotherapy in the United Kingdom–a web-based survey
JWG Roe, PN Carding, PH Rhys-Evans, KL Newbold… - Oral oncology, 2012 - Elsevier
We undertook a service evaluation to establish how oropharyngeal dysphagia is managed
in head and neck cancer patients receiving radiotherapy in the United Kingdom. A web-…
in head and neck cancer patients receiving radiotherapy in the United Kingdom. A web-…
The predictive value of early assessment after 1 cycle of induction chemotherapy with 18F-FDG PET/CT and diffusion-weighted MRI for response to radical …
…, WJG Oyen, K Harrington, KL Newbold - Journal of Nuclear …, 2016 - Soc Nuclear Med
The objective of this study was to assess the predictive value of early assessment (after 1
cycle of induction chemotherapy [IC]) with 18 F-FDG PET/CT and diffusion-weighted (DW) MRI …
cycle of induction chemotherapy [IC]) with 18 F-FDG PET/CT and diffusion-weighted (DW) MRI …
[HTML][HTML] Changes in multimodality functional imaging parameters early during chemoradiation predict treatment response in patients with locally advanced head and …
…, WJ Oyen, KJ Harrington, KL Newbold - European journal of …, 2018 - Springer
Objective To assess the optimal timing and predictive value of early intra-treatment changes
in multimodality functional and molecular imaging (FMI) parameters as biomarkers for …
in multimodality functional and molecular imaging (FMI) parameters as biomarkers for …
Noninvasive imaging of cycling hypoxia in head and neck cancer using intrinsic susceptibility MRI
…, SA Eccles, MO Leach, SP Robinson, KL Newbold - Clinical Cancer …, 2017 - AACR
Purpose: To evaluate intrinsic susceptibility (IS) MRI for the identification of cycling hypoxia,
and the assessment of its extent and spatial distribution, in head and neck squamous cell …
and the assessment of its extent and spatial distribution, in head and neck squamous cell …
[HTML][HTML] HSP90 inhibition sensitizes head and neck cancer to platin-based chemoradiotherapy by modulation of the DNA damage response resulting in chromosomal …
…, R Patel, JN Kyula, SA Bhide, KL Newbold… - BMC cancer, 2017 - Springer
Background Concurrent cisplatin radiotherapy (CCRT) is a current standard-of-care for
locally advanced head and neck squamous cell carcinoma (HNSCC). However, CCRT is …
locally advanced head and neck squamous cell carcinoma (HNSCC). However, CCRT is …