A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring
tRNA pools in various cell types, we found two distinct subsets, one that is induced in …

This study investigates the challenge of comprehensively cataloging the complete human
proteome from a single-cell type using mass spectrometry (MS)-based shotgun proteomics. …

Alternative splicing enhances proteome diversity and modulates cancer-associated proteins.
To identify tissue- and tumor-specific alternative splicing, we used the GeneChip Human …

In our study, whole‐genome methylation arrays were applied to identify novel genes with
tumor specific DNA methylation of promoter CpG islands in pre‐malignant and malignant …

Purpose Diagnostic and prognostic tools for prostate cancer (PC) are suboptimal, causing
overtreatment of indolent PC and risk of delayed treatment of aggressive PC. Here, we identify …

Context Short noncoding RNAs known as microRNAs (miRNAs) control protein expression
through the degradation of RNA or the inhibition of protein translation. The miRNAs influence …

Background Widespread use of prostate-specific antigen (PSA) testing for prostate cancer (PC)
detection has led to extensive overdiagnosis and overtreatment. Urine-based microRNA (…

Prostate cancer (PC) is the most frequent cancer in men in the Western world. Currently,
serum prostate-specific antigen levels and digital rectal examinations are used to indicate the …

With the largest high-risk prostate cancer (PCa) cohort to date undergoing 68 Ga-prostate-specific
membrane antigen (PSMA) PET/CT primary staging, we aimed to, first, characterize …

Purpose: Available tools for prostate cancer diagnosis and prognosis are suboptimal and
novel biomarkers are urgently needed. Here, we investigated the regulation and biomarker …