Many recent studies have emphasized the deleterious role of inflammation in CNS injury.
Increases in free fatty acids, eicosanoids, and products of lipid peroxidation are known to occur …

The distribution of β-amyloid precursor protein (APP) was examined immunocytochemically
in rats subjected to focal cerebral ischemia by permanent occlusion of the middle cerebral …

The oxidative stress responsive transcription factor nuclear factor-κB (NF-κB) consists of a
p50 (50 kDa) and p65/RelA (65 kDa) component and can be activated in vitro by TNFα, IL1β, …

Kappa-opioid receptors (KOR) are believed to be involved in the pathophysiology of depression,
anxiety disorders, drug abuse, and alcoholism. To date, only 1 tracer, the KOR agonist …

Arylphenylpyrrolidinylmethylphenoxybenzamides were found to have high affinity and
selectivity for κ opioid receptors. On the basis of receptor binding assays in Chinese hamster …

Nociceptin/OFQ (N/OFQ) is a 17 amino acid peptide that is the endogenous ligand for the
ORL1/NOP receptor. Nociceptin appears to regulate a host of physiological functions such as …

High performance liquid chromatography combined with either single quad or triple quad
mass spectral detectors (LC/MS) was used to measure the brain distribution of receptor …

Preclinical brain receptor occupancy measures have heretofore been conducted by
quantifying the brain distribution of a radiolabeled tracer ligand using either scintillation …

Positron emission tomography (PET) coupled to an effective radioligand could provide an
important tool for understanding possible links between neuropsychiatric disorders and brain …

Our laboratory developed (S)-3-(2′-fluoro-6′,7′-dihydrospiro[piperidine-4,4′-thieno[3,2-c]pyran]-1-yl)-2-(2-fluorobenzyl)-N-methylpropanamide
( 11 C-NOP-1A), a new radioligand …