Docosahexaenoic acid (DHA; 22:6n-3) is a critical constituent of the brain, but its metabolism
has not been measured in the human brain in vivo. In monkeys, using positron emission …

Male rat pups (21 days old) were placed on a diet deficient in n‐3 polyunsaturated fatty
acids (PUFAs) or on an n‐3 PUFA adequate diet containing α‐linolenic acid (α‐LNA; 18 : 3n‐3). …

Adult male unanesthetized rats, reared on a diet enriched in both α‐linolenic acid (α‐LNA)
and docosahexaenoic acid (DHA), were infused intravenously for 5 min with [1‐ 14 C]α‐LNA. …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
brain deposition of senile (neuritic) plaques containing amyloid-β, neurofibrillary tangles, …

Rates of conversion of α-linolenic acid (α-LNA, 18:3n-3) to docosahexaenoic acid (DHA, 22:6n-3)
by the mammalian brain and the brain's ability to upregulate these rates during dietary …

Fifteen weeks of dietary n-3 PUFA deprivation increases coefficients of conversion of circulating
α-linolenic acid (α-LNA; 18:3n-3) to docosahexaenoic acid (DHA; 22:6n-3) in rat liver but …

The extent to which the adult brain can derive some of its arachidonic acid (AA) through
internalized synthesis from linoleic acid (LA) is uncertain. Thus, we determined for plasma-…

BACKGROUND: Disturbances in prefrontal cortex phospholipid and fatty acid composition
have been reported in patients with schizophrenia (SCZ), often as an incomplete lipid profile …

We quantified incorporation rates of plasma-derived α-linolenic acid (α-LNA, 18:3n-3) into "stable"
liver lipids and the conversion rate of α-LNA to docosahexaenoic acid (DHA, 22:6n-3) …

Reduced concentrations of docosahexaenoic acid (DHA, 22:6n−3) and arachidonic acid (AA,
20:4n−6) have been reported in the postmortem bipolar disorder (BD) brain. Additionally, …