There is a dire need for new antimicrobial compounds to combat the growing threat of
widespread antibiotic resistance. With a currently very scarce drug pipeline, consisting mostly of …

Seven rhenium(I) complexes of the general formula fac-[Re(CO) 3 (NN)(OH 2 )] + where NN
= 2,2′-bipyridine (8), 4,4′-dimethyl-2,2′-bipyridine (9), 4,4′-dimethoxy-2,2′-bipyridine (…

The endoplasmic reticulum (ER) has recently emerged as a promising target for anticancer
agents. Cytotoxic compounds that target the ER often exhibit selectivity for cancer cells over …

The 18‐membered macrocycle H 2 macropa was investigated for 225 Ac chelation in
targeted alpha therapy (TAT). Radiolabeling studies showed that macropa, at submicromolar …

The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for use …

The demonstration in the 1960s that cis-diamminedichloroplatinum (II), or cisplatin, inhibits
cellular division of Escherichia coli 1 led to the subsequent discovery that this simple …

Fifteen water-soluble rhenium compounds of the general formula [Re(CO) 3 (NN)(PR 3 )] + ,
where NN is a diimine ligand and PR 3 is 1,3,5-triaza-7-phosphaadamantane (PTA), tris(…

Lanthanides (Ln 3+ ) are critical materials used for many important applications, often in the
form of coordination compounds. Tuning the thermodynamic stability of these compounds is …

Monofunctional platinum(II) complexes of general formula cis-[Pt(NH 3 ) 2 (N-heterocycle)Cl]Cl
bind DNA at a single site, inducing little distortion in the double helix. Despite this …

Platinum compounds represent one of the great success stories of metals in medicine. Following
the serendipitous discovery of the anticancer activity of cisplatin by Rosenberg, a large …