Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage

…, RB Zheng, P Zhang, C Nycholat, JJ Bailey… - Nature chemical …, 2021 - nature.com
The central dogma of biology does not allow for the study of glycans using DNA sequencing.
We report a liquid glycan array (LiGA) platform comprising a library of DNA ‘barcoded’ M13 …

From Unorthodox to Established: The Current Status of 18F-Trifluoroborate- and 18F-SiFA-Based Radiopharmaceuticals in PET Nuclear Imaging

V Bernard-Gauthier, JJ Bailey, Z Liu… - Bioconjugate …, 2016 - ACS Publications
Unorthodox 18 F-labeling strategies not employing the formation of a carbon- 18 F bond are
seldom found in radiochemistry. Historically, the formation of a boron- or silicon- 18 F bond …

Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 – Part II

JJ Bailey, R Schirrmacher, K Farrell… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: TrkA/B/C receptor activation supports growth, survival, and differentiation of
discrete neuronal populations during development, adult life, and ageing but also plays …

[HTML][HTML] Self-adjuvanting glycopeptide conjugate vaccine against disseminated candidiasis

H Xin, J Cartmell, JJ Bailey, S Dziadek, DR Bundle… - PloS one, 2012 - journals.plos.org
Our research on pathogenesis of disseminated candidiasis led to the discovery that antibodies
specific for Candida albicans cell surface β-1, 2–mannotriose [β-(Man) 3 ] protect mice. A …

Recent advances in 18F radiochemistry: a focus on B-18F, Si-18F, Al-18F, and C-18F radiofluorination via spirocyclic iodonium ylides

…, ML Lepage, B Waengler, JJ Bailey… - Journal of Nuclear …, 2018 - Soc Nuclear Med
Straightforward radiosynthesis protocols for 18 F-labeled radiopharmaceuticals are an
indispensable but often overlooked prerequisite to successfully perform molecular imaging …

Automated synthesis of PET radiotracers by copper‐mediated 18F‐fluorination of organoborons: Importance of the order of addition and competing protodeborylation

…, V Bernard‐Gauthier, JJ Bailey… - Journal of Labelled …, 2018 - Wiley Online Library
In this paper, we describe the use of Cu‐mediated [ 18 F]fluorodeboronation for the automated
production of positron emission tomography radiotracers suitable for clinical use. Two …

Radiosynthesis of [18F]SiFAlin-TATE for clinical neuroendocrine tumor positron emission tomography

S Lindner, C Wängler, JJ Bailey, K Jurkschat… - Nature …, 2020 - nature.com
Here, we describe an extension of our silicon fluoride acceptor (SiFA) protocol for 18 F-labeling
of peptides that addresses challenges associated with preparing a clinical-grade (Tyr 3 )-…

[HTML][HTML] Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) 18F-Radiopharmaceuticals

…, L Beyer, S Lindner, K Jurkschat, B Wängler, JJ Bailey… - Pharmaceuticals, 2021 - mdpi.com
The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules,
such as peptides, proteins and biologically relevant small molecules, has improved the …

Identification of [18F]TRACK, a Fluorine-18-Labeled Tropomyosin Receptor Kinase (Trk) Inhibitor for PET Imaging

…, JJ Bailey, X Shao, J Stauff, J Arteaga… - Journal of Medicinal …, 2018 - ACS Publications
Changes in expression and dysfunctional signaling of TrkA/B/C receptors and oncogenic
Trk fusion proteins are found in neurological diseases and cancers. Here, we describe the …

Tropomyosin receptor kinase inhibitors: an updated patent review for 2016–2019

JJ Bailey, C Jaworski, D Tung, C Wängler… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction: Tropomyosin receptor kinases (Trks) control processes in the fields of growth,
survival, and differentiation of neuronal processes. They also play a crucial role in …