Recent advances in cancer therapeutics, such as targeted therapy and immunotherapy,
have raised the hope for cures for many cancer types. However, there are still ongoing …

We report a method of cancer immunotherapy using an attenuated Salmonella typhimurium
strain engineered to secrete Vibrio vulnificus flagellin B (FlaB) in tumor tissues. Engineered …

In response to microbial infection, expression of the defensin-like peptide hepcidin (encoded
by Hamp) is induced in hepatocytes to decrease iron release from macrophages 1 . To …

Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain;
however, the roles of GABA in antimicrobial host defenses are largely unknown. Here we …

There is growing interest in the role of microorganisms in human health and disease, with
evidence showing that new types of biotherapy using engineered bacterial therapeutics, …

Conventional chemotherapies have some limitations, including the lack of selectivity, high
toxicity to normal tissues, multidrug resistance, and tumor relapse. Recently, great progress …

A number of recent reports have demonstrated that attenuated Salmonella typhimurium are
capable of targeting both primary and metastatic tumors. The use of bacteria as a vehicle for …

Advances in genetic engineering tools have contributed to the development of strategies for
utilizing biologically derived vesicles as nanomedicines for achieving cell-specific drug …

Background— The current method of analyzing myocardial cell transplantation relies on
postmortem histology. We sought to demonstrate the feasibility of monitoring transplanted cell …

Tumor-targeting bacteria have been studied in terms of their ability to visualize the infection
pathway (through imaging probes) or to carry therapeutic molecules to tumors. To integrate …