Interest in serotonergic involvement in Parkinson's disease (PD) has focussed recently on the
possibility that the remaining serotonin neurons innervating striatum (caudate and putamen…

α-Synuclein is a major component of Lewy bodies and glial cytoplasmic inclusions,
pathological hallmarks of idiopathic Parkinson's disease and multiple system atrophy, and it is …

Positron emission tomography (PET) imaging of monoamine oxidases (MAO-A: [ 11 C]harmine,
[ 11 C]clorgyline, and [ 11 C]befloxatone; MAO-B: [ 11 C]deprenyl-D2) has been actively …

INTRODUCTION: The primary approach in assessing the status of brain serotonin neurons
in human conditions such as major depression and exposure to the illicit drug ecstasy has …

Positron emission tomography (PET) findings suggesting lower D 2 -type dopamine receptors
and dopamine concentration in brains of stimulant users have prompted speculation that …

Animal data indicate that the recreational drug ecstasy (3,4-methylenedioxymethamphetamine)
can damage brain serotonin neurons. However, human neuroimaging measurements of …

See Jellinger (doi: 10.1093/awx190 ) for a scientific commentary on this article. The enzyme
monoamine oxidases (B and A subtypes, encoded by MAOB and MAOA, respectively) are …

Although gliosis is a normal response to brain injury, reports on the extent of astrogliosis in
the degenerating substantia nigra in Parkinson’s disease (PD) are conflicting. It has also …

The dopamine system is a primary treatment target for cocaine dependence (CD), but research
on dopaminergic abnormalities (eg, D 2 receptor system deficiencies) has so far failed to …

The D 3 dopamine (DA) receptor is a member of the D 2 -like DA receptor family. While the D
2 receptor is abundant especially in motor-regions of the striatum, the D 3 receptor shows a …