Optimization of radioimmunotherapy of renal cell carcinoma: labeling of monoclonal antibody cG250 with 131I, 90Y, 177Lu, or 186Re

AH Brouwers, JEM van Eerd, C Frielink… - Journal of Nuclear …, 2004 - Soc Nuclear Med
Radioimmunotherapy (RIT) can be performed with various radionuclides. We tested the
stability, biodistribution, and therapeutic efficacy of various radioimmunoconjugates ( 131 I, 88/…

Gelatin-based plasma expander effectively reduces renal uptake of 111In-octreotide in mice and rats

JEM van Eerd, E Vegt, JFM Wetzels… - Journal of nuclear …, 2006 - Soc Nuclear Med
111 In-Diethylenetriaminepentaacetic acid-octreotide generally is used for the scintigraphic
imaging of neuroendocrine and other somatostatin receptor–positive tumors. On the basis of …

Reducing renal uptake of radiolabeled peptides using albumin fragments

E Vegt, JEM van Eerd, A Eek, WJG Oyen… - Journal of Nuclear …, 2008 - Soc Nuclear Med
In most types of peptide receptor radionuclide therapy, the maximum activity dose that can
be administered is limited by high and persistent renal retention of the radiolabeled peptides, …

Long-lived positron emitters zirconium-89 and iodine-124 for scouting of therapeutic radioimmunoconjugates with PET

…, GWM Visser, OC Boerman, JEM Van Eerd… - Cancer Biotherapy …, 2003 - liebertpub.com
Antibody-PET imaging might be of value for the selection of radioimmunotherapy (RIT)
candidates to confirm tumor targeting and to estimate radiation doses to tumor and normal tissues…

A bivalent leukotriene B4 antagonist for scintigraphic imaging of infectious foci

JEM van Eerd, WJG Oyen, TD Harris… - Journal of Nuclear …, 2003 - Soc Nuclear Med
Several radiolabeled chemotactic peptides have been tested for their suitability to show
infection and inflammation. Leukotriene B 4 (LTB 4 ) receptor-binding ligands could be useful …

PET Radioimmunoscintigraphy of Renal Cell Cancer Using 89Zr-Labeled cG250 Monoclonal Antibody in Nude Rats

A Brouwers, I Verel, J Van Eerd, G Visser… - Cancer Biotherapy …, 2004 - liebertpub.com
Introduction: With the introduction of positron-emitting radionuclides with half-lifes in days,
such as 89 Zr and 124 I, radioimmunoscintigraphy (RIS) with positron-emitter-labeled …

Timing of adjuvant radioimmunotherapy after cytoreductive surgery in experimental peritoneal carcinomatosis of colorectal origin

F Aarts, MJ Koppe, T Hendriks, JEM van Eerd… - Annals of surgical …, 2007 - Springer
Background Treatment of patients with peritoneal carcinomatosis (PC) of colorectal cancer (CRC)
includes cytoreductive surgery (CS) in combination with (hyperthermic) intraperitoneal …

Scintigraphic detection of pulmonary aspergillosis in rabbits with a radiolabeled leukotriene b4 antagonist

JEM van Eerd, HJJM Rennen, WJG Oyen… - Journal of Nuclear …, 2004 - Soc Nuclear Med
Radiolabeled chemotactic peptides have been studied for their applicability to the
visualization of infectious and inflammatory foci. Because a radiolabeled leukotriene B4 (LTB4) …

Scintigraphic imaging of infectious foci with an 111In-LTB4 antagonist is based on in vivo labeling of granulocytes

JEM van Eerd, WJG Oyen, TD Harris… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Radiolabeled leukotriene B4 (LTB4) antagonist DPC11870 is able to reveal infectious and
inflammatory foci in distinct animal models. Because previous studies showed that …

Imaging of infection and inflammation with an improved 99mTc-labeled LTB4 antagonist

JEM van Eerd, M Broekema, TD Harris… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Studies have demonstrated that the bivalent 111 In-labeled leukotriene B4 (LTB4) antagonist
DPC11870 reveals infectious and inflammatory lesions in various rabbit models. The …