Early Detection of Tumor Response to Chemotherapy by 3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography: The Effect of Cisplatin on a Fibrosarcoma Tumor …
J Leyton, JR Latigo, M Perumal, H Dhaliwal, Q He… - Cancer research, 2005 - AACR
We have assessed the potential of [ 18 F]fluorothymidine positron emission tomography ([
18 F]FLT-PET) to measure early cytostasis and cytotoxicity induced by cisplatin treatment of …
18 F]FLT-PET) to measure early cytostasis and cytotoxicity induced by cisplatin treatment of …
Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging
MD Allen, P Luong, C Hudson, J Leyton, B Delage… - Cancer research, 2014 - AACR
Targeted therapies have yet to have significant impact on the survival of patients with bladder
cancer. In this study, we focused on the urea cycle enzyme argininosuccinate synthetase 1 …
cancer. In this study, we focused on the urea cycle enzyme argininosuccinate synthetase 1 …
[HTML][HTML] Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging
R Goldstein, J Sosabowski, M Livanos, J Leyton… - European journal of …, 2015 - Springer
Purpose Human epidermal growth factor receptor-2 (HER2) overexpression is a predictor of
response to anti-HER2 therapy in breast and gastric cancer. Currently, HER2 status is …
response to anti-HER2 therapy in breast and gastric cancer. Currently, HER2 status is …
Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission …
Thymidylate synthase (EC 2.1.1.45) is a key enzyme for the de novo synthesis of DNA and
as such a target for anticancer drug development. There is a need to develop noninvasive …
as such a target for anticancer drug development. There is a need to develop noninvasive …
Synthesis and in vitro evaluation of [18F] fluoroethyl triazole labelled [Tyr3] octreotate analogues using click chemistry
L Iddon, J Leyton, B Indrevoll, M Glaser… - Bioorganic & medicinal …, 2011 - Elsevier
A novel class of alkyne linked [Tyr 3 ]octreotate analogues have been labelled by a copper
catalysed azide-alkyne cycloaddition reaction (CuAAC) to form a 1,4-substituted triazole …
catalysed azide-alkyne cycloaddition reaction (CuAAC) to form a 1,4-substituted triazole …
Targeting somatostatin receptors: preclinical evaluation of novel 18F-fluoroethyltriazole-Tyr3-octreotate analogs for PET
J Leyton, L Iddon, M Perumal, B Indrevoll… - Journal of nuclear …, 2011 - Soc Nuclear Med
The incidence and prevalence of gastroenteropancreatic neuroendocrine tumors has been
increasing over the past 3 decades. Because of high densities of somatostatin receptors (sstr)…
increasing over the past 3 decades. Because of high densities of somatostatin receptors (sstr)…
In vivo Biological Activity of the Histone Deacetylase Inhibitor LAQ824 Is detectable with 3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography
J Leyton, JP Alao, M Da Costa, AV Stavropoulou… - Cancer Research, 2006 - AACR
Histone deacetylase inhibitors (HDACI) are emerging as growth inhibitory compounds that
modulate gene expression and inhibit tumor cell proliferation. We assessed whether 3′-…
modulate gene expression and inhibit tumor cell proliferation. We assessed whether 3′-…
Radiosynthesis and pre-clinical evaluation of [18F] fluoro-[1, 2-2H4] choline
G Smith, Y Zhao, J Leyton, B Shan, M Perumal… - Nuclear medicine and …, 2011 - Elsevier
INTRODUCTION: Choline radiotracers are widely used for clinical PET diagnosis in oncology.
[ 11 C]Choline finds particular utility in the imaging of brain and prostate tumor metabolic …
[ 11 C]Choline finds particular utility in the imaging of brain and prostate tumor metabolic …
VIP receptor antagonists and chemotherapeutic drugs inhibit the growth of breast cancer cells
TW Moody, J Leyton, D Chan, DC Brenneman… - Breast cancer research …, 2001 - Springer
The effects of vasoactive intestinal peptide (VIP) antagonists on breast cancer cells were
investigated. (N-stearyl, norleucine 17 )VIP hybrid ((SN)VIPhyb) inhibited specific 125 I-VIP …
investigated. (N-stearyl, norleucine 17 )VIP hybrid ((SN)VIPhyb) inhibited specific 125 I-VIP …
Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901
J Leyton, G Smith, M Lees, M Perumal, Q Nguyen… - Molecular Cancer …, 2008 - AACR
The mitogenic extracellular kinase 1/2 (MEK1/2) inhibitor, PD0325901, has potent activity in
a number of cancer cell types in vitro. In SKMEL-28 human melanoma cells (BRAF mutant), …
a number of cancer cell types in vitro. In SKMEL-28 human melanoma cells (BRAF mutant), …