Monitoring tumor response to antiangiogenic sunitinib therapy with 18F-fluciclatide, an 18F-labeled αvβ3-integrin and αvβ5-integrin imaging agent
MR Battle, JL Goggi, L Allen, J Barnett… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Arginine-glycine-aspartate (RGD)-binding α V β 3 -integrin and α V β 5 -integrin play key
roles in tumor angiogenesis. We examined an 18 F-labeled small peptide (fluciclatide [United …
roles in tumor angiogenesis. We examined an 18 F-labeled small peptide (fluciclatide [United …
Reissner fibre-induced urotensin signalling from cerebrospinal fluid-contacting neurons prevents scoliosis of the vertebrate spine
Reissner fibre (RF), discovered by the 19 th -century German anatomist Ernst Reissner, is a
filamentous structure present in cerebrospinal fluid (CSF). RF forms by aggregation of a …
filamentous structure present in cerebrospinal fluid (CSF). RF forms by aggregation of a …
[HTML][HTML] Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans
…, AK Groen, F Kuipers, JL Goggi… - The Journal of …, 2022 - Am Soc Clin Investig
BACKGROUND Cytochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12α-hydroxylated
bile acids (BAs) that are associated with insulin resistance in humans. …
bile acids (BAs) that are associated with insulin resistance in humans. …
[HTML][HTML] Granzyme B PET imaging of combined chemotherapy and immune checkpoint inhibitor therapy in colon cancer
JL Goggi, SV Hartimath, TY Xuan, S Khanapur… - Molecular Imaging and …, 2021 - Springer
Purpose Chemotherapeutic adjuvants, such as oxaliplatin (OXA) and 5-fluorouracil (5-FU),
that enhance the immune system, are being assessed as strategies to improve durable …
that enhance the immune system, are being assessed as strategies to improve durable …
[HTML][HTML] CAV1-GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer
…, JT Teo, JG Clohessy, JL Goggi, C Wu, L Chen… - Theranostics, 2019 - ncbi.nlm.nih.gov
Background: The development of molecular targeted therapies, such as EGFR-TKIs, has
positively impacted the management of EGFR mutated NSCLC. However, patients with innate …
positively impacted the management of EGFR mutated NSCLC. However, patients with innate …
Functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome phenotype
…, EY Tao, SLM Ong, JL Goggi… - Human Molecular …, 2018 - academic.oup.com
Winchester syndrome (WS, MIM #277950) is an extremely rare autosomal recessive skeletal
dysplasia characterized by progressive joint destruction and osteolysis. To date, only one …
dysplasia characterized by progressive joint destruction and osteolysis. To date, only one …
Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin
…, SA Charman, EG Robins, JL Goggi… - ACS pharmacology & …, 2020 - ACS Publications
We describe a cysteine-rich, membrane-penetrating, joint-targeting, and remarkably stable
peptide, EgK5, that modulates voltage-gated K V 1.3 potassium channels in T lymphocytes by …
peptide, EgK5, that modulates voltage-gated K V 1.3 potassium channels in T lymphocytes by …
Crosstalk between CD64+MHCII+ macrophages and CD4+ T cells drives joint pathology during chikungunya
Communications between immune cells are essential to ensure appropriate coordination of
their activities. Here, we observed the infiltration of activated macrophages into the joint-…
their activities. Here, we observed the infiltration of activated macrophages into the joint-…
Examining immunotherapy response using multiple radiotracers
JL Goggi, SV Hartimath, Y Hwang, YX Tan… - Molecular Imaging and …, 2020 - Springer
Purpose Cancer immunotherapy has shown huge potential in the fight against cancer, but
only a small proportion of patients respond successfully to treatment. Non-invasive methods to …
only a small proportion of patients respond successfully to treatment. Non-invasive methods to …
[HTML][HTML] Imaging Kv1. 3 expressing memory T cells as a marker of immunotherapy response
Simple Summary Cancer immunotherapy has shown huge potential in the fight against
cancer but few patients respond durably to treatment. Durable immunological responses are …
cancer but few patients respond durably to treatment. Durable immunological responses are …