The clinical value of current and future nanomedicines can be improved by introducing patient
selection strategies based on noninvasive sensitive whole-body imaging techniques such …

The magnetic properties and safety of dextran-coated superparamagnetic iron oxide
nanoparticles (SPIONs) have facilitated their clinical use as MRI contrast agents and stimulated …

Poly(ADP-ribose) polymerase (PARP) inhibitors are increasingly being studied as cancer
drugs, as single agents, or as a part of combination therapies. Imaging of PARP using a …

Two new bifunctional tris(hydroxypyridinone) (THP) chelators designed specifically for rapid
labeling with 68 Ga have been synthesized, each with pendant isothiocyanate groups and …

Alzheimer disease (AD) is a fatal neurodegenerative disorder characterized by progressive
neuronal loss and cognitive decline. The lack of reliable and objective diagnostic markers for …

Due to compromised homologous recombination ( HR ) repair, BRCA 1‐ and BRCA 2‐mutated
tumours accumulate DNA damage and genomic rearrangements conducive of tumour …

Molecular radiotherapy using 177 Lu-DOTATATE is a most effective treatment for somatostatin
receptor–expressing neuroendocrine tumors. Despite its frequent and successful use in …

Background [ 18 F]BF 4 − , the first 18 F-labelled PET imaging agent for the sodium/iodide
symporter (NIS), was produced by isotopic exchange yielding a product with limited specific …

Overexpression of tight-junction protein claudin-4 has been detected in primary and metastatic
pancreatic cancer tissue and is associated with better prognosis in patients. Noninvasive …

Purpose Despite its widespread use, the positron emission tomography (PET) radiotracer 2-deoxy-2-[
18 F]fluoro-D-glucose ([ 18 F]FDG) has been shown in clinical settings to be …