Striatal dopamine D1 and D2 receptors in burning mouth syndrome

N Hagelberg, H Forssell, JO Rinne, H Scheinin… - Pain, 2003 - Elsevier
Animal studies have indicated that the nigrostriatal dopaminergic system is involved in central
pain modulation. In a recent positron emission tomography (PET) study, we demonstrated …

The use of PET in Alzheimer disease

A Nordberg, JO Rinne, A Kadir… - Nature Reviews …, 2010 - nature.com
In Alzheimer disease (AD), which is the most common cause of dementia, the underlying
disease pathology most probably precedes the onset of cognitive symptoms by many years. …

Functional imaging studies of dopamine system and cognition in normal aging and Parkinson's disease

V Kaasinen, JO Rinne - Neuroscience & Biobehavioral Reviews, 2002 - Elsevier
Modern functional imaging methods, such as positron emission tomography (PET) and single
photon emission computed tomography (SPECT), provide non-invasive, quantitative tools …

The pedunculopontine nucleus: its role in the genesis of movement disorders

MS Lee, JO Rinne, CD Marsden - Yonsei medical journal, 2000 - eymj.org
The pedunculopontine nucleus (PPN) is located in the dorso-lateral part of the ponto-mesencephalic
tegmentum. The PPN is composed of two groups of neurons: one containing …

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis

…, IHGB Ramakers, L Rami, CR De Oliveira, JO Rinne… - Jama, 2015 - jamanetwork.com
Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid …

Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis

…, MA Mintun, DA Wolk, A Nordberg, JO Rinne… - Jama, 2015 - jamanetwork.com
Importance Amyloid-β positron emission tomography (PET) imaging allows in vivo detection
of fibrillar plaques, a core neuropathological feature of Alzheimer disease (AD). Its …

Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C] PIB positron emission tomography

P Edison, CC Rowe, JO Rinne, S Ng… - Journal of Neurology …, 2008 - jnnp.bmj.com
Background: Neuropathological studies have reported varying amounts of amyloid
pathology in dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD). [11C]PIB …

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo …

JO Rinne, DJ Brooks, MN Rossor, NC Fox… - The Lancet …, 2010 - thelancet.com
Background Carbon-11-labelled Pittsburgh compound B ( 11 C-PiB) PET is a marker of
cortical fibrillar amyloid-β load in vivo. We used 11 C-PiB PET to investigate whether …

[HTML][HTML] Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer's disease: a phase 1b, randomized, placebo-controlled trial

…, S Ducharme, M Jonsson, A Schneider, JO Rinne… - Nature medicine, 2023 - nature.com
Tau plays a key role in Alzheimer’s disease (AD) pathophysiology, and accumulating
evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT …

Parkinsonism, premature menopause, and mitochondrial DNA polymerase γ mutations: clinical and molecular genetic study

P Luoma, A Melberg, JO Rinne, JA Kaukonen… - The Lancet, 2004 - thelancet.com
Background Mutations in the gene encoding mitochondrial DNA polymerase γ (POLG), the
enzyme that synthesises mitochondrial DNA (mtDNA), have been associated with a …