Mutations in critical genes are believed to be a necessary part of cancer induction. The
conventional view of radiation mutagenesis is that radiation induces most mutations in cells …

α-emitting radionuclides are highly cytotoxic and are of considerable interest in the treatment
of cancer. A particularly interesting approach is in radioimmunotherapy. However, α-…

Background Genomic instability is characteristic of many types of human cancer. Recently,
we reported that ultraviolet radiation induced elevated mutation rates and chromosomal …

Treatment of MDCK II cells with the lipophilic photosensitizer tetra(3-hydroxyphenyl)porphyrin
and light was found to induce a rapid apoptotic response in a large fraction of the cells. …

Background Clonogenic assays are used frequently to measure the cell killing and mutagenic
effects of radiation and other agents. Clonogenic assays carried out manually are tedious …

Background The aim of the present study was to explore the biodistribution, normal tissue
toxicity, and therapeutic efficacy of the internalizing low-dose rate alpha-particle-emitting …

Radioimmunotherapy has proven clinically effective in patients with non-Hodgkin's lymphoma.
Radioimmunotherapy trials have so far been performed with β-emitting isotopes. In …

The monoclonal antibody against CD20, rituximab, alone, or as part of combination therapies,
is standard therapy for non-Hodgkin's B-cell lymphoma. Despite significantly better clinical …

For patients with indolent non-Hodgkin lymphoma who fail initial anti-CD20–based
immunochemotherapy or develop relapsed or refractory disease, there remains a significant unmet …

Background The aim of this study was to investigate therapeutic efficacy and normal tissue
toxicity of single dosage and fractionated targeted alpha therapy (TAT) in mice with HER2-…