Background Major depressive disorder is associated with raised peripheral inflammatory
markers. Mounting evidence also suggests that inflammation is involved in suicidal behavior. …

Pathologic deposition of amyloid β (Aβ) protein is a key component in the pathogenesis of
Alzheimer disease (AD) but not a feature of frontotemporal dementia (FTD). PET ligands for …

Amyloid-beta (Aβ) deposition is common in cognitively unimpaired (CU) elderly >85 years.
This study investigated amyloid distribution and evaluated three published in vivo amyloid-…

Background Despite increased recognition of cognitive impairment in Multiple System Atrophy
(MSA), its neuroanatomical correlates are not well defined. We aimed to explore cognitive …

Patient motion during PET scans introduces errors in the attenuation correction and image
blurring leading to false changes in regional radioactivity concentrations. However, the …

… Jose M. Anton-Rodriguez was undertaking a Ph.D. supported by The Christie NHS …
Anton-Rodriguez are also with the Christie Medical Physics and Engineering, The Christie …

Objective: To investigate whether [18 F] fluorothymidine (FLT) and/or [18 F] fluorodeoxyglucose
(FDG) positron emission tomography (PET) can differentiate growth in neurofibromatosis …

Although motion correction in medical imaging is well established and has attracted much
interest and research funding, a gap still exists in that there is a lack of reliable, low-cost …

In this work we compare spatially variant radioisotope-specific point spread functions (PSFs)
derived from published positron range data with measured data using a high resolution …

Brain dedicated scanners such as the High Resolution Research Tomograph (HRRT) can
achieve spatial resolutions of 2-3 mm FWHM due to their small scintillators crystal size and a …