[HTML][HTML] Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications

J Löfblom, J Feldwisch, V Tolmachev, J Carlsson… - FEBS letters, 2010 - Elsevier
Affibody molecules are a class of engineered affinity proteins with proven potential for
therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5kDa) …

Tumor imaging using a picomolar affinity HER2 binding affibody molecule

…, I Höidén-Guthenberg, C Widström, J Carlsson… - Cancer research, 2006 - AACR
The detection of cell-bound proteins that are produced due to aberrant gene expression in
malignant tumors can provide important diagnostic information influencing patient …

Selection and characterization of HER2/neu-binding affibody ligands

…, V Tolmachev, GP Adams, J Carlsson… - Protein Engineering …, 2004 - academic.oup.com
Affibody® (affibody) ligands that are specific for the extracellular domain of human epidermal
growth factor receptor 2 (HER2/neu) have been selected by phage display technology from …

[HTML][HTML] HER2 expression in breast cancer primary tumours and corresponding metastases. Original data and literature review

J Carlsson, H Nordgren, J Sjöström, K Wester… - British journal of …, 2004 - nature.com
The aim of this study was to evaluate whether the HER2 expression in breast cancer is retained
in metastases. The HER2 expression in primary tumours and the corresponding lymph …

First-in-human molecular imaging of HER2 expression in breast cancer metastases using the 111In-ABY-025 affibody molecule

…, U Garske-Román, J Carlsson… - Journal of nuclear …, 2014 - Soc Nuclear Med
The expression status of human epidermal growth factor receptor type 2 (HER2) predicts
the response of HER2-targeted therapy in breast cancer. ABY-025 is a small reengineered …

Radionuclide Therapy of HER2-Positive Microxenografts Using a 177Lu-Labeled HER2-Specific Affibody Molecule

…, K Andersson, M Sandström, D Rosik, J Carlsson… - Cancer research, 2007 - AACR
A radiolabeled anti-HER2 Affibody molecule (Z HER2:342 ) targets HER2-expressing xenografts
with high selectivity and gives good imaging contrast. However, the small size (∼7 kDa…

[HTML][HTML] Measuring HER2-receptor expression in metastatic breast cancer using [68Ga] ABY-025 Affibody PET/CT

…, M Sandström, M Lubberink, H Olofsson, J Carlsson… - Theranostics, 2016 - ncbi.nlm.nih.gov
Purpose: Positron Emission Tomography (PET) imaging of HER2 expression could potentially
be used to select patients for HER2-targed therapy, predict response based on uptake …

A review of dsb induction data for varying quality radiations

KM Prise, G Ahnström, M Belli, J Carlsson… - … journal of radiation …, 1998 - Taylor & Francis
Purpose: This short review summarizes the data obtained with various techniques for
measuring the yields of double strand breaks (dsb) produced by particle radiations of differing …

Demonstration of an extracellular matrix in multicellular tumor spheroids

T Nederman, B Norling, B Glimelius, J Carlsson… - Cancer research, 1984 - AACR
Multicellular spheroids of a human glioma cell line (U-118 MG) and a human thyroid cancer
cell line (HTH-7) were analyzed for the presence of extracellular matrix (ECM) using light …

Boron neutron capture therapy for glioblastoma multiforme: clinical studies in Sweden

…, E Wallin, A Brun, L Franzen, J Carlsson… - Journal of neuro …, 2003 - Springer
A boron neutron capture therapy (BNCT) facility has been constructed at Studsvik, Sweden.
It includes two filter/moderator configurations. One of the resulting neutron beams has been …