User profiles for Jonathan Graff-Radford

Jonathan Graff-Radford

Mayo Clinic
Verified email at mayo.edu
Cited by 12094

New insights into atypical Alzheimer's disease in the era of biomarkers

J Graff-Radford, KXX Yong, LG Apostolova… - The Lancet …, 2021 - thelancet.com
Most patients with Alzheimer's disease present with amnestic problems; however, a substantial
proportion, over-represented in young-onset cases, have atypical phenotypes including …

Associations of amyloid, tau, and neurodegeneration biomarker profiles with rates of memory decline among individuals without dementia

…, CG Schwarz, JL Gunter, ML Senjem, J Graff-Radford… - Jama, 2019 - jamanetwork.com
Importance A National Institute on Aging and Alzheimer’s Association workgroup proposed
a research framework for Alzheimer disease in which biomarker classification of research …

Consensus classification of posterior cortical atrophy

…, J GraffRadford, NR GraffRadford… - Alzheimer's & …, 2017 - Wiley Online Library
Introduction A classification framework for posterior cortical atrophy (PCA) is proposed to
improve the uniformity of definition of the syndrome in a variety of research settings. Methods …

Performance of plasma phosphorylated tau 181 and 217 in the community

…, VJ Lowe, G Bu, P Vemuri, J Graff-Radford… - Nature medicine, 2022 - nature.com
Plasma phosphorylated tau 181 (P-tau181) and 217 (P-tau217) are indicators of both amyloid
and tau pathology in clinical settings, but their performance in heterogeneous community-…

Cascading network failure across the Alzheimer's disease spectrum

DT Jones, DS Knopman, JL Gunter, J Graff-Radford… - Brain, 2016 - academic.oup.com
Complex biological systems are organized across various spatiotemporal scales with particular
scientific disciplines dedicated to the study of each scale (eg genetics, molecular biology …

Longitudinal tau PET in ageing and Alzheimer's disease

…, DS Knopman, JL Gunter, DT Jones, J Graff-Radford… - Brain, 2018 - academic.oup.com
See Hansson and Mormino (doi: 10.1093/brain/awy065 ) for a scientific commentary on this
article. Our objective was to compare different whole-brain and region-specific …

Comparison of plasma phosphorylated tau species with amyloid and tau positron emission tomography, neurodegeneration, vascular pathology, and cognitive …

…, V Lowe, G Bu, P Vemuri, J Graff-Radford… - JAMA …, 2021 - jamanetwork.com
Importance Cerebrospinal fluid phosphorylated tau (p-tau) 181, p-tau217, and p-tau231 are
associated with neuropathological outcomes, but a comparison of these p-tau isoforms in …

Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: Combined data from 13 community-based or population …

…, BN Dugger, JF Ervin, J Fleming, J Graff-Radford… - Acta …, 2022 - Springer
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC)
and Alzheimer’s disease neuropathologic change (ADNC) are each associated with …

Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study

…, BF Boeve, DS Knopman, NR Graff-Radford… - The Lancet …, 2020 - thelancet.com
Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with
about a third of cases being genetic. Most of this genetic component is accounted for by …

Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia

…, K Kantarci, DT Jones, P Vemuri, J Graff-Radford… - Brain, 2018 - academic.oup.com
See Herholz (doi: 10.1093/brain/awx340 ) for a scientific commentary on this article. Autopsy
data have proposed that a topographical pattern of tauopathy occurs in the brain with the …