User profiles for Jonathan Graff-Radford
Jonathan Graff-RadfordMayo Clinic Verified email at mayo.edu Cited by 12094 |
New insights into atypical Alzheimer's disease in the era of biomarkers
Most patients with Alzheimer's disease present with amnestic problems; however, a substantial
proportion, over-represented in young-onset cases, have atypical phenotypes including …
proportion, over-represented in young-onset cases, have atypical phenotypes including …
Associations of amyloid, tau, and neurodegeneration biomarker profiles with rates of memory decline among individuals without dementia
Importance A National Institute on Aging and Alzheimer’s Association workgroup proposed
a research framework for Alzheimer disease in which biomarker classification of research …
a research framework for Alzheimer disease in which biomarker classification of research …
Consensus classification of posterior cortical atrophy
…, J Graff‐Radford, NR Graff‐Radford… - Alzheimer's & …, 2017 - Wiley Online Library
Introduction A classification framework for posterior cortical atrophy (PCA) is proposed to
improve the uniformity of definition of the syndrome in a variety of research settings. Methods …
improve the uniformity of definition of the syndrome in a variety of research settings. Methods …
Performance of plasma phosphorylated tau 181 and 217 in the community
…, VJ Lowe, G Bu, P Vemuri, J Graff-Radford… - Nature medicine, 2022 - nature.com
Plasma phosphorylated tau 181 (P-tau181) and 217 (P-tau217) are indicators of both amyloid
and tau pathology in clinical settings, but their performance in heterogeneous community-…
and tau pathology in clinical settings, but their performance in heterogeneous community-…
Cascading network failure across the Alzheimer's disease spectrum
DT Jones, DS Knopman, JL Gunter, J Graff-Radford… - Brain, 2016 - academic.oup.com
Complex biological systems are organized across various spatiotemporal scales with particular
scientific disciplines dedicated to the study of each scale (eg genetics, molecular biology …
scientific disciplines dedicated to the study of each scale (eg genetics, molecular biology …
Longitudinal tau PET in ageing and Alzheimer's disease
…, DS Knopman, JL Gunter, DT Jones, J Graff-Radford… - Brain, 2018 - academic.oup.com
See Hansson and Mormino (doi: 10.1093/brain/awy065 ) for a scientific commentary on this
article. Our objective was to compare different whole-brain and region-specific …
article. Our objective was to compare different whole-brain and region-specific …
Comparison of plasma phosphorylated tau species with amyloid and tau positron emission tomography, neurodegeneration, vascular pathology, and cognitive …
…, V Lowe, G Bu, P Vemuri, J Graff-Radford… - JAMA …, 2021 - jamanetwork.com
Importance Cerebrospinal fluid phosphorylated tau (p-tau) 181, p-tau217, and p-tau231 are
associated with neuropathological outcomes, but a comparison of these p-tau isoforms in …
associated with neuropathological outcomes, but a comparison of these p-tau isoforms in …
Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: Combined data from 13 community-based or population …
…, BN Dugger, JF Ervin, J Fleming, J Graff-Radford… - Acta …, 2022 - Springer
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC)
and Alzheimer’s disease neuropathologic change (ADNC) are each associated with …
and Alzheimer’s disease neuropathologic change (ADNC) are each associated with …
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study
…, BF Boeve, DS Knopman, NR Graff-Radford… - The Lancet …, 2020 - thelancet.com
Background Frontotemporal dementia is a heterogenous neurodegenerative disorder, with
about a third of cases being genetic. Most of this genetic component is accounted for by …
about a third of cases being genetic. Most of this genetic component is accounted for by …
Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia
See Herholz (doi: 10.1093/brain/awx340 ) for a scientific commentary on this article. Autopsy
data have proposed that a topographical pattern of tauopathy occurs in the brain with the …
data have proposed that a topographical pattern of tauopathy occurs in the brain with the …