MicroRNAs (miRNAs) circulate in the bloodstream in a highly stable, extracellular form and
are being developed as blood-based biomarkers for cancer and other diseases. However, …

Circulating, cell-free microRNAs (miRNAs) hold great promise as a new class of cancer
biomarkers due to their surprisingly high stability in plasma, association with disease states, and …

Whereas unperturbed endothelial cells provide potent anticoagulant properties, exposure to
inflammatory and atherogenic stimuli can rapidly lead to a procoagulant behavior. Because …

One of the earliest events in programmed cell death is the externalization of phosphatidylserine,
a membrane phospholipid normally restricted to the inner leaflet of the lipid bilayer. …

Increased exposure of phosphatidylserine (PS) in erythrocytes has been postulated to
contribute to the pathophysiology of sickle cell disease because of its possible effects on blood …

Circulating, cell-free microRNAs (miRNAs) are promising candidate biomarkers, but optimal
conditions for processing blood specimens for miRNA measurement remain to be …

A hypermutated subtype of advanced prostate cancer was recently described, but prevalence
and mechanisms have not been well-characterized. Here we find that 12% (7 of 60) of …

Recent years have seen development and implementation of anticancer therapies targeted
to particular gene mutations, but methods to assay clinical cancer specimens in a …

Results: Membrane-bound radiolabeled annexin V activity lin early correlated to total
fluorescence as observed by FITC annexin V flow cytometry in Jurkat T-cell cultures induced to …

Lynch syndrome (hereditary nonpolyposis colon cancer) and adenomatous polyposis
syndromes frequently have overlapping clinical features. Current approaches for molecular …