In vivo imaging of human 11C-metformin in peripheral organs: dosimetry, biodistribution, and kinetic analyses

LC Gormsen, EI Sundelin, JB Jensen… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Metformin is the most widely prescribed oral antiglycemic drug, with few adverse effects.
However, surprisingly little is known about its human biodistribution and target tissue …

[PDF][PDF] Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients

J Farup, J Just, F De Paoli, L Lin, JB Jensen… - Cell metabolism, 2021 - cell.com
Type 2 diabetes mellitus (T2DM) is associated with impaired skeletal muscle function and
degeneration of the skeletal muscles. However, the mechanisms underlying the degeneration …

Genetic polymorphisms in organic cation transporter 1 attenuates hepatic metformin exposure in humans

EIO Sundelin, LC Gormsen, JB Jensen… - Clinical …, 2017 - Wiley Online Library
Metformin has been used successfully to treat type 2 diabetes for decades. However, the
efficacy of the drug varies considerably from patient to patient and this may in part be due to its …

[HTML][HTML] A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals

JB Jensen, OL Dollerup, AB Møller, TB Billeskov… - JCI insight, 2022 - ncbi.nlm.nih.gov
BACKGROUND During aging, there is a functional decline in the pool of muscle stem cells (MuSCs)
that influences the functional and regenerative capacity of skeletal muscle. …

[HTML][HTML] Efficient correction of Duchenne muscular dystrophy mutations by SpCas9 and dual gRNAs

…, J Yu, S Li, X Liang, P Han, K Qu, JB Jensen… - … Therapy-Nucleic Acids, 2021 - cell.com
CRISPR gene therapy is one promising approach for treatment of Duchenne muscular
dystrophy (DMD), which is caused by a large spectrum of mutations in the dystrophin gene. To …

Metformin biodistribution: a key to mechanisms of action?

E Sundelin, JB Jensen, S Jakobsen… - The Journal of …, 2020 - academic.oup.com
Metformin has undisputed glucose-lowering effects in diabetes and an impressive safety
record. It has also shown promising effects beyond diabetes, and several hundred clinical trials …

Fast diffusion kurtosis imaging of fibrotic mouse kidneys

…, A Chuhutin, L Pedersen, JB Jensen… - NMR in …, 2016 - Wiley Online Library
Diffusion kurtosis imaging (DKI) is sensitive to tissue microstructure and may therefore be
useful in the diagnosis and monitoring of disease in brain and body organs. Generally, …

A PET tracer for renal organic cation transporters, 11C-metformin: radiosynthesis and preclinical proof-of-concept studies

S Jakobsen, M Busk, JB Jensen, OL Munk… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Organic cation transporters (OCTs) in the kidney proximal tubule (PT) participate in renal
excretion of drugs and endogenous compounds. PT function is commonly impaired in kidney …

[HTML][HTML] Fluorescence-activated cell sorting and phenotypic characterization of human fibro-adipogenic progenitors

TB Billeskov, JB Jensen, N Jessen, J Farup - STAR protocols, 2023 - Elsevier
The ability of stem cells to activate and differentiate is critical for maintaining the regenerative
capacity of skeletal muscle. Here, we detail steps for specific quantification and isolation of …

[HTML][HTML] Renal PET-imaging with 11C-metformin in a transgenic mouse model for chronic kidney disease

L Pedersen, JB Jensen, L Wogensen, OL Munk… - EJNMMI research, 2016 - Springer
Background Organic cation transporters (OCTs) in the renal proximal tubule are important
for the excretion of both exo- and endogenous compounds, and chronic kidney disease (CKD) …