In vivo imaging of human 11C-metformin in peripheral organs: dosimetry, biodistribution, and kinetic analyses
LC Gormsen, EI Sundelin, JB Jensen… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Metformin is the most widely prescribed oral antiglycemic drug, with few adverse effects.
However, surprisingly little is known about its human biodistribution and target tissue …
However, surprisingly little is known about its human biodistribution and target tissue …
[PDF][PDF] Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients
Type 2 diabetes mellitus (T2DM) is associated with impaired skeletal muscle function and
degeneration of the skeletal muscles. However, the mechanisms underlying the degeneration …
degeneration of the skeletal muscles. However, the mechanisms underlying the degeneration …
Genetic polymorphisms in organic cation transporter 1 attenuates hepatic metformin exposure in humans
EIO Sundelin, LC Gormsen, JB Jensen… - Clinical …, 2017 - Wiley Online Library
Metformin has been used successfully to treat type 2 diabetes for decades. However, the
efficacy of the drug varies considerably from patient to patient and this may in part be due to its …
efficacy of the drug varies considerably from patient to patient and this may in part be due to its …
[HTML][HTML] A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals
JB Jensen, OL Dollerup, AB Møller, TB Billeskov… - JCI insight, 2022 - ncbi.nlm.nih.gov
BACKGROUND During aging, there is a functional decline in the pool of muscle stem cells (MuSCs)
that influences the functional and regenerative capacity of skeletal muscle. …
that influences the functional and regenerative capacity of skeletal muscle. …
[HTML][HTML] Efficient correction of Duchenne muscular dystrophy mutations by SpCas9 and dual gRNAs
…, J Yu, S Li, X Liang, P Han, K Qu, JB Jensen… - … Therapy-Nucleic Acids, 2021 - cell.com
CRISPR gene therapy is one promising approach for treatment of Duchenne muscular
dystrophy (DMD), which is caused by a large spectrum of mutations in the dystrophin gene. To …
dystrophy (DMD), which is caused by a large spectrum of mutations in the dystrophin gene. To …
Metformin biodistribution: a key to mechanisms of action?
E Sundelin, JB Jensen, S Jakobsen… - The Journal of …, 2020 - academic.oup.com
Metformin has undisputed glucose-lowering effects in diabetes and an impressive safety
record. It has also shown promising effects beyond diabetes, and several hundred clinical trials …
record. It has also shown promising effects beyond diabetes, and several hundred clinical trials …
Fast diffusion kurtosis imaging of fibrotic mouse kidneys
…, A Chuhutin, L Pedersen, JB Jensen… - NMR in …, 2016 - Wiley Online Library
Diffusion kurtosis imaging (DKI) is sensitive to tissue microstructure and may therefore be
useful in the diagnosis and monitoring of disease in brain and body organs. Generally, …
useful in the diagnosis and monitoring of disease in brain and body organs. Generally, …
A PET tracer for renal organic cation transporters, 11C-metformin: radiosynthesis and preclinical proof-of-concept studies
S Jakobsen, M Busk, JB Jensen, OL Munk… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Organic cation transporters (OCTs) in the kidney proximal tubule (PT) participate in renal
excretion of drugs and endogenous compounds. PT function is commonly impaired in kidney …
excretion of drugs and endogenous compounds. PT function is commonly impaired in kidney …
[HTML][HTML] Fluorescence-activated cell sorting and phenotypic characterization of human fibro-adipogenic progenitors
TB Billeskov, JB Jensen, N Jessen, J Farup - STAR protocols, 2023 - Elsevier
The ability of stem cells to activate and differentiate is critical for maintaining the regenerative
capacity of skeletal muscle. Here, we detail steps for specific quantification and isolation of …
capacity of skeletal muscle. Here, we detail steps for specific quantification and isolation of …
[HTML][HTML] Renal PET-imaging with 11C-metformin in a transgenic mouse model for chronic kidney disease
L Pedersen, JB Jensen, L Wogensen, OL Munk… - EJNMMI research, 2016 - Springer
Background Organic cation transporters (OCTs) in the renal proximal tubule are important
for the excretion of both exo- and endogenous compounds, and chronic kidney disease (CKD) …
for the excretion of both exo- and endogenous compounds, and chronic kidney disease (CKD) …