The incidence of oesophageal adenocarcinoma (EAC) is steeply rising. Early lesion detection
is a critical factor for improving disease prognosis. We developed and investigated wide-…

Background and purpose The RAPIDO trial demonstrated a decrease in disease-related
treatment failure (DrTF) and an increase in pathological complete responses (pCR) in locally …

Adenoma miss rates in colonoscopy are unacceptably high, especially for sessile serrated
adenomas/polyps (SSA/Ps) and in high-risk populations, such as patients with Lynch …

Negative circumferential resection margins (CRM) are the cornerstone for the curative
treatment of locally advanced rectal cancer (LARC). However, in up to 18.6% of patients, tumor-…

Quantitative fluorescence endoscopy (QFE) is a new technique that can visualise and quantify
fluorescently tagged tumour tissue. In 25 patients with locally advanced rectal cancer (…

Small and flat adenomas are known to carry a high miss-rate during standard white-light
endoscopy. Increased detection rate may be achieved by molecular fluorescence endoscopy …

White-light surveillance colonoscopy is the standard of care for the detection and removal of
premalignant lesions to prevent colorectal cancer, and the main screening recommendation …

Rationale: Negative circumferential resection margins (CRM) are the cornerstone for curative
treatment of locally advanced rectal cancer (LARC). However, in up to 18.6% of patients …

Small and flat adenomas are known to carry a high miss-rate during standard white-light
endoscopy. Increased detection rate may be achieved by molecular-guided endoscopy with …

The known limitations of clinically available endoscopes initiated a search for novel imaging
techniques that allow improved detection of early oesophageal lesions. FME is heralded as …