Apart from well-defined factors in neuronal cells 1 , only a few reports consider that the
variability of sporadic amyotrophic lateral sclerosis (ALS) progression can depend on less-…

Importance During a time with the potential for novel treatment strategies, early detection of
disease manifestations at an individual level in presymptomatic carriers of a hexanucleotide …

Background Prevalence estimates of suicidal thoughts and behaviours (STB) among
clinically active healthcare professionals during the first wave of COVID19 pandemic are non-…

Neuroinflammation is important in amyotrophic lateral sclerosis (ALS). The P2X7 receptor (P2X7R)
is a promising target for neuroinflammation. The objective of this study was to …

Amyotrophic lateral sclerosis (ALS) is characterized by progressive loss of upper and lower
motor neurons. In 10% of patients, the disorder runs in the family. Our aim was to study the …

Purpose Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder
with on average a 1-year delay between symptom onset and diagnosis. Studies have …

Neuroinflammation has been implicated in amyotrophic lateral sclerosis (ALS) and can be
visualized using translocator protein (TSPO) radioligands. To become a reliable …

Full article: Multicenter validation of [18F]-FDG PET and support-vector machine discriminant
analysis in automatically classifying patients with amyotrophic lateral sclerosis versus …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by the
progressive loss of motor neurons in the brain, the brainstem and the spinal cord. 1 This results …

Background: The Edinburgh cognitive and behavioral ALS screen (ECAS) was developed
specifically to detect cognitive and behavioral changes in patients with amyotrophic lateral …