Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction
…, N Nozaki, S Yamaguchi, Y Shibata, J Nitobe… - Circulation, 2003 - Am Heart Assoc
Background— Toll-like receptors (TLRs) are members of the interleukin-1 receptor family
and transduce similar signals as interleukin-1 receptor in response to exogenous pathogens. …
and transduce similar signals as interleukin-1 receptor in response to exogenous pathogens. …
High serum level of pentosidine, an advanced glycation end product (AGE), is a risk factor of patients with heart failure
…, N Nozaki, O Hirono, Y Tsunoda, J Nitobe… - Journal of cardiac …, 2007 - Elsevier
BACKGROUND: Pentosidine, one of the advanced glycation end products (AGE), is generated
by nonenzymatic glycation and oxidation of proteins. The receptor of AGE (RAGE) is …
by nonenzymatic glycation and oxidation of proteins. The receptor of AGE (RAGE) is …
Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes
J Nitobe, S Yamaguchi, M Okuyama… - Cardiovascular …, 2003 - academic.oup.com
Objective: Fas ligand (FasL) is a key cytokine which initiates apoptosis when FasL binds to its
receptor, Fas. Cardiac myocytes are generally resistant to Fas-induced apoptosis. However…
receptor, Fas. Cardiac myocytes are generally resistant to Fas-induced apoptosis. However…
Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage in chronic heart failure patients
…, N Nozaki, O Hirono, T Watanabe, J Nitobe… - Journal of cardiac …, 2007 - Elsevier
BACKGROUND: Heart-type fatty acid-binding protein (H-FABP) is a small cytosolic protein
and released into the circulation when the myocardium is injured. Previous studies have …
and released into the circulation when the myocardium is injured. Previous studies have …
Serum resistin is associated with high risk in patients with congestive heart failure a novel link between metabolic signals and heart failure
…, T Arimoto, N Nozaki, O Hirono, J Nitobe… - Circulation …, 2007 - jstage.jst.go.jp
Background Resistin is derived from fat tissue in rodents, and serum levels are elevated in
animal models of obesity and insulin resistance. Recent studies have reported that resistin is …
animal models of obesity and insulin resistance. Recent studies have reported that resistin is …
Prognostic value of elevated circulating heart-type fatty acid binding protein in patients with congestive heart failure
…, H Tachibana, N Nozaki, O Hirono, J Nitobe… - Journal of cardiac …, 2005 - Elsevier
BACKGROUND: Heart-type fatty acid binding protein (H-FABP) is released into the
circulation when the myocardium is injured and is a novel marker for the diagnosis of acute …
circulation when the myocardium is injured and is a novel marker for the diagnosis of acute …
Apoptosis in rat cardiac myocytes induced by Fas ligand: priming for Fas-mediated apoptosis with doxorubicin
…, S Yamaguchi, T Suzuki, M Okuyama, J Nitobe… - Journal of Molecular and …, 2000 - Elsevier
M. Yamaoka, S. Yamaguchi, T. Suzuki, M. Okuyama, J. Nitobe, N. Nakamura, Y. Mitsui and H.
Tomoike. Apoptosis in Rat Cardiac Myocytes Induced by Fas Ligand: Priming for Fas-…
Tomoike. Apoptosis in Rat Cardiac Myocytes Induced by Fas Ligand: Priming for Fas-…
Persistently increased serum concentration of heart-type fatty acid-binding protein predicts adverse clinical outcomes in patients with chronic heart failure
…, N Nozaki, O Hirono, T Watanabe, J Nitobe… - Circulation …, 2008 - jstage.jst.go.jp
Background Heart-type fatty acid-binding protein (H-FABP) is a small cytosolic protein that is
released into the circulation when the myocardium is injured. This study examined whether …
released into the circulation when the myocardium is injured. This study examined whether …
Increased left atrial volume index predicts a poor prognosis in patients with heart failure
…, T Shishido, T Miyashita, T Miyamoto, J Nitobe… - Journal of Cardiac …, 2011 - Elsevier
BACKGROUND: Left atrial volume index (LAVI) is known to reflect the duration and severity
of increased left atrial pressure caused by left ventricular (LV) diastolic dysfunction. However…
of increased left atrial pressure caused by left ventricular (LV) diastolic dysfunction. However…
Risk stratification of chronic heart failure patients by multiple biomarkers implications of BNP, h-FABP, and PTX3
…, Y Takeishi, T Niizeki, T Watanabe, J Nitobe… - Circulation …, 2008 - jstage.jst.go.jp
Background B-type natriuretic peptide (BNP), heart-type fatty acid-binding protein (H-FABP),
and pentraxin 3 (PTX3) each predict adverse cardiac events in chronic heart failure (CHF) …
and pentraxin 3 (PTX3) each predict adverse cardiac events in chronic heart failure (CHF) …