Successful treatment of prolonged, severe coronavirus disease 2019 lower respiratory tract disease in a B cell acute lymphoblastic leukemia patient with an extended …
…, LH Yoke, AB Braimah, JJ Orozco… - Clinical Infectious …, 2023 - academic.oup.com
A patient with B-cell acute lymphoblastic leukemia (ALL) and severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) had persistent, progressive pneumonia with viremia after …
coronavirus 2 (SARS-CoV-2) had persistent, progressive pneumonia with viremia after …
Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model
…, SHL Frost, AK Gopal, JJ Orozco… - Blood, The Journal …, 2015 - ashpublications.org
α-Emitting radionuclides deposit a large amount of energy within a few cell diameters and
may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD)…
may be particularly effective for radioimmunotherapy targeting minimal residual disease (MRD)…
CD38-bispecific antibody pretargeted radioimmunotherapy for multiple myeloma and other B-cell malignancies
…, AK Gopal, TA Gooley, JJ Orozco… - Blood, The Journal …, 2018 - ashpublications.org
Pretargeted radioimmunotherapy (PRIT) has demonstrated remarkable efficacy targeting
tumor antigens, but immunogenicity and endogenous biotin blocking may limit clinical …
tumor antigens, but immunogenicity and endogenous biotin blocking may limit clinical …
Quantitative single‐particle digital autoradiography with α‐particle emitters for targeted radionuclide therapy using the iQID camera
…, DK Hamlin, DS Wilbur, DR Fisher, JJ Orozco… - Medical …, 2015 - Wiley Online Library
Purpose: Alpha‐emitting radionuclides exhibit a potential advantage for cancer treatments
because they release large amounts of ionizing energy over a few cell diameters (50–80 μm), …
because they release large amounts of ionizing energy over a few cell diameters (50–80 μm), …
Anti-CD45 radioimmunotherapy using 211At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model
JJ Orozco, T Bäck, A Kenoyer, ER Balkin… - Blood, The Journal …, 2013 - ashpublications.org
Despite aggressive chemotherapy combined with hematopoietic stem cell transplantation (HSCT),
many patients with acute myeloid leukemia (AML) relapse. Radioimmunotherapy (RIT…
many patients with acute myeloid leukemia (AML) relapse. Radioimmunotherapy (RIT…
The α-emitter astatine-211 targeted to CD38 can eradicate multiple myeloma in a disseminated disease model
S O'Steen, ML Comstock, JJ Orozco… - Blood, The Journal …, 2019 - ashpublications.org
Minimal residual disease (MRD) has become an increasingly prevalent and important entity
in multiple myeloma (MM). Despite deepening responses to frontline therapy, roughly 75% …
in multiple myeloma (MM). Despite deepening responses to frontline therapy, roughly 75% …
A preclinical model of CD38-pretargeted radioimmunotherapy for plasma cell malignancies
…, AL Kenoyer, SL Frayo, AK Gopal, JJ Orozco… - Cancer research, 2014 - AACR
The vast majority of patients with plasma cell neoplasms die of progressive disease despite
high response rates to novel agents. Malignant plasma cells are very radiosensitive, but the …
high response rates to novel agents. Malignant plasma cells are very radiosensitive, but the …
[HTML][HTML] cGMP production of astatine-211-labeled anti-CD45 antibodies for use in allogeneic hematopoietic cell transplantation for treatment of advanced …
…, RL Manger, M Nartea, AL Kenoyer, JJ Orozco… - PLoS …, 2018 - journals.plos.org
The objective of this study was to translate reaction conditions and quality control methods
used for production of an astatine-211( 211 At)-labeled anti-CD45 monoclonal antibody (MAb…
used for production of an astatine-211( 211 At)-labeled anti-CD45 monoclonal antibody (MAb…
[HTML][HTML] Pretransplantation minimal residual disease predicts survival in patients with mantle cell lymphoma undergoing autologous stem cell transplantation in …
…, TR Chauncey, SD Smith, M Philip, JJ Orozco… - Biology of Blood and …, 2016 - Elsevier
Autologous stem cell transplantation (ASCT) is standard therapy for mantle cell lymphoma (MCL)
in remission after induction chemotherapy, with the best results for patients in complete …
in remission after induction chemotherapy, with the best results for patients in complete …
Anti-CD45 pretargeted radioimmunotherapy using bismuth-213: high rates of complete remission and long-term survival in a mouse myeloid leukemia xenograft …
…, S Frayo, A Axtman, N Orgun, J Orozco… - Blood, The Journal …, 2011 - ashpublications.org
Pretargeted radioimmunotherapy (PRIT) using an anti-CD45 antibody (Ab)–streptavidin (SA)
conjugate and DOTA-biotin labeled with β-emitting radionuclides has been explored as a …
conjugate and DOTA-biotin labeled with β-emitting radionuclides has been explored as a …