Background Prophylactic cranial irradiation has been a standard treatment in children with
acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) …

Background and Methods. Treatment of cancer with the epipodophyllotoxins (etoposide and
teniposide) has been linked to the development of acute myeloid leukemia (AML) in …

BACKGROUND: Patients with acute lymphoblastic leukemia are often treated with 6-mercaptopurine,
and those with homozygous deficiency in thiopurine S-methyltransferase (TPMT) …

By using rapid flow cytometric techniques capable of detecting one leukemic cell in 10 4
normal cells, we prospectively studied minimal residual disease (MRD) in 195 children with …

St Jude Total Therapy Study XIIIB for childhood acute lymphoblastic leukemia (ALL)
incorporated more stringent risk classification, early intensification of intrathecal chemotherapy, …

Lymphomas are the third most common group of cancers in children and adolescents in the
United States, accounting for approximately 13 percent of newly diagnosed cancers in this …

Background Children who survive acute lymphoblastic leukemia are at risk for leukemia-related
or treatment-related complications, which can adversely affect survival and …

Early clearance of leukemic cells is a favorable prognostic indicator in childhood acute
lymphoblastic leukemia (ALL). However, identification of residual leukemic cells by their …

Purpose Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic
leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors …

Somatic alterations of the lymphoid transcription factor gene PAX5 (also known as BSAP) are
a hallmark of B cell precursor acute lymphoblastic leukemia (B-ALL) 1 , 2 , 3 , but inherited …