Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Background In patients with stable coronary artery disease, it remains unclear whether an
initial management strategy of percutaneous coronary intervention (PCI) with intensive …

strongly with insulin resistance. Excess upper body fat can accumulate either intraperitoneally
(visceral fat) or subcutaneously. Many investigators claim that excess visceral fat is more …

We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

Background— Extent and severity of myocardial ischemia are determinants of risk for patients
with coronary artery disease, and ischemia reduction is an important therapeutic goal. The …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted as the document was compiled through …

Background Among patients with stable coronary disease and moderate or severe ischemia,
whether clinical outcomes are better in those who receive an invasive intervention plus …

(ACCF) guidelines on secondary prevention, 1 important evidence from clinical trials has
emerged that further supports and broadens the merits of intensive risk-reduction therapies for …

OBJECTIVES To create a valid, sensitive, disease-specific health status measure for patients
with congestive heart failure (CHF). BACKGROUND Quantifying health status is becoming …

Background— Although drug-eluting stents (DES) significantly reduce restenosis, they
require 3 to 6 months of thienopyridine therapy to prevent stent thrombosis. The rate and …