Background: To characterize further behavioral, cognitive, neuroendocrine, and physiological
effects of subanesthetic doses of ketamine hydrochloride in healthy human subjects. …

The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic
transmission is associated with this illness, but direct observation of abnormalities of dopamine …

Objective Studies in nonhuman primates suggest that high levels of cortisol associated with
stress have neurotoxic effects on the hippocampus, a brain structure involved in memory. …

The Parkinson Progression Marker Initiative (PPMI) is a comprehensive observational,
international, multi-center study designed to identify PD progression biomarkers both to improve …

OBJECTIVE: The authors previously observed an increase in striatal dopamine transmission
following amphetamine challenge in 15 untreated patients with schizophrenia compared to …

Introduction We studied whether fully automated Elecsys cerebrospinal fluid (CSF)
immunoassay results were concordant with positron emission tomography (PET) and predicted …

Objective To compare initial treatment with pramipexole vs levodopa in early Parkinson
disease, followed by levodopa supplementation, with respect to the development of …

BACKGROUND: Nonlocalizing neurologic deficits detectable by clinical evaluation–“soft
signs”–are a robust finding in patients diagnosed with schizophrenia, but their conceptual and …

Background: Prior research has suggested reductions in the density of serotonin transporter
(SERT) binding sites in blood platelets and post-mortem brain tissue of depressed patients. …

Background Imaging with amyloid-β PET can potentially aid the early and accurate
diagnosis of Alzheimer's disease. Florbetaben ( 18 F) is a promising 18 F-labelled amyloid-β-…