User profiles for John Schaus
 | John SchausFellow, International Security Program, CSIS Verified email at csis.org Cited by 366 |
Countering coercion in maritime Asia: The theory and practice of gray zone deterrence
In the past decade, tensions in Asia have risen as Beijing has become more assertive in
maritime disputes with its neighbors and the United States. Although taking place below the …
maritime disputes with its neighbors and the United States. Although taking place below the …
5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs
KW Johnson, JM Schaus, MM Durkin, JE Audia… - …, 1997 - journals.lww.com
THE serotonin (5-HT) receptor subtype mediating inhibition of neurogenic dural inflammation
in guinea pigs was investigated using a series of serotonin agonists with differing affinities …
in guinea pigs was investigated using a series of serotonin agonists with differing affinities …
Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats
…, SM Nielsen, MN Poulsen, JM Schaus… - International Journal …, 2010 - academic.oup.com
The in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT 6 R
antagonist Lu AE58054 ([2-(6-fluoro-1H-indol-3-yl)-ethyl]-[3-(2,2,3,3-tetrafluoropropoxy)-benzyl]-…
antagonist Lu AE58054 ([2-(6-fluoro-1H-indol-3-yl)-ethyl]-[3-(2,2,3,3-tetrafluoropropoxy)-benzyl]-…
Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using 18F-labeled inverse agonist radioligands
…, R Gladding, JT Tauscher, JM Schaus… - Journal of Nuclear …, 2010 - Soc Nuclear Med
We recently demonstrated that 11 C-MePPEP, a PET ligand for CB 1 receptors, has such high
uptake in the human brain that it can be imaged for 210 min and that receptor density can …
uptake in the human brain that it can be imaged for 210 min and that receptor density can …
Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand
…, AG Farris, A Lerner, JT Tauscher, JM Schaus… - Neuroimage, 2009 - Elsevier
[ 11 C]MePPEP is a high affinity, CB 1 receptor-selective, inverse agonist that has been
studied in rodents and monkeys. We examined the ability of [ 11 C]MePPEP to quantify CB 1 …
studied in rodents and monkeys. We examined the ability of [ 11 C]MePPEP to quantify CB 1 …
[HTML][HTML] The PET radioligand [11C] MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain
…, E Chernet, J Tauscher, JM Schaus… - …, 2008 - nature.com
The cannabinoid CB 1 receptor is one of the most abundant G protein-coupled receptors in
the brain and is a promising target of therapeutic drug development. Success of drug …
the brain and is a promising target of therapeutic drug development. Success of drug …
Synthesis, ex vivo evaluation, and radiolabeling of potent 1, 5-diphenylpyrrolidin-2-one cannabinoid subtype-1 receptor ligands as candidates for in vivo imaging
…, CC Felder, C Halldin, JM Schaus - Journal of medicinal …, 2008 - ACS Publications
We have reported that [methyl- 11 C] (3R,5R)-5-(3-methoxyphenyl)-3-[(R)-1-phenylethylamino]-1-(4-trifluoromethylphenyl)pyrrolidin-2-one
([ 11 C]8, [ 11 C]MePPEP) binds with high …
([ 11 C]8, [ 11 C]MePPEP) binds with high …
Synthesis and Pharmacological Characterization of 2-(2, 6-Dichlorophenyl)-1-((1 S, 3 R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3, 4 …
J Hao, JP Beck, JM Schaus, JH Krushinski, Q Chen… - 2019 - ACS Publications
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor
has thus far been unsuccessful due to multiple challenges. To address these issues, we …
has thus far been unsuccessful due to multiple challenges. To address these issues, we …
[HTML][HTML] Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders
…, MJ O'Neill, TK Murray, BJ Eastwood, JM Schaus… - …, 2018 - Elsevier
DETQ, an allosteric potentiator of the dopamine D1 receptor, was tested in therapeutic models
that were known to respond to D1 agonists. Because of a species difference in affinity for …
that were known to respond to D1 agonists. Because of a species difference in affinity for …
The role of 5-HT1A receptors in control of lower urinary tract function in cats
…, MA Katofiasc, H Danuser, J Springer, JM Schaus - Brain research, 2002 - Elsevier
In the present study, the role of 5-HT 1A receptors in control of lower urinary tract function in
cats was examined using 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and 5-…
cats was examined using 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and 5-…