Development of cancer receptor-specific gold nanoparticles will allow efficient targeting/optimum
retention of engineered gold nanoparticles within tumors and thus provide synergistic …

Systemic delivery of therapeutic agents to solid tumors is hindered by vascular and
interstitial barriers. We hypothesized that prostate tumor specific epigallocatechin-gallate (EGCg) …

Approximately 192,280 men are diagnosed with prostate cancer every year, resulting in loss
of life for 27,360 men in the United States and 288,000 men worldwide if not treated in its …

As we celebrate the bicentennial of the isolation of morphine by Sertürner, opioids continue
to dominate major sectors of the analgesic market worldwide. The pharmaceutical industry …

We examined the mechanisms involved in protein kinase C (PKC)‐dependent down‐regulation
of dopamine transporter (DAT) activity and cell surface expression by treating …

SA4503, a potent σ 1 receptor agonist, is reported as having 103‐fold higher affinity for σ 1 (IC
50 = 17.4 nM) than σ 2 (IC 50 = 1784 nM) sites in guinea pig brain membranes. Modest …

Introduction Aspects of radiopharmaceutical development are illustrated through preclinical
studies of [ 125 I]-(E)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-4-(iodoallyl)piperazine ([ 125 I]-…

Recently, we have developed the positron emitting radiotracer N1′-([11 C] methyl) naltrindole
([11 C] MeNTI) and demonstrated its high selectivity for δ opioid receptors in the mouse …

… Address reprint requests to John R. Lever, Ph.D., Room 2001 Hume, Johns Hopkins
University School of Hygiene and Public Health, 615 North Wolfe Street, Baltimore, MD 21205, or …

Alterations in a variety of neurotransmitter systems have been identified in experimental models
of epilepsy and in brain tissue from patients with intractable temporal lobe seizures. The …