Cystic fibrosis transmembrane regulator (CFTR), the gene product that is mutated in cystic
fibrosis (CF) patients, has a well-recognized function as a cyclic adenosine 3′,5′-…

Background Cystic fibrosis is a monogenic disease that deranges multiple systems of ion
transport in the airways, culminating in chronic infection and destruction of the lung. The …

Salmonella constitutes a genus of zoonotic bacteria of worldwide economic and health
importance. The current view of salmonella taxonomy assigns the members of this genus to two …

Cystic fibrosis (CF) patients are hypersusceptible to chronic Pseudomonas aeruginosa lung
infections. Cultured human airway epithelial cells expressing the ΔF508 allele of the cystic …

In photosynthesis, the harvesting of solar energy and its subsequent conversion into a stable
charge separation are dependent upon an interconnected macromolecular network of …

An important issue for in vivo gene therapy for cystic fibrosis (CF) is the percentage of cells
within the CF airway that will require correction. In this study, we mixed populations of a CF …

The Cl- secretory pathway that is defective in cystic fibrosis (CF) can be bypassed by an
alternative pathway for Cl- transport that is activated by extracellular nucleotides. Accordingly, …

Background Many patients with chronic pulmonary disease similar to that seen in cystic
fibrosis have normal (or nondiagnostic) sweat chloride values. It has been difficult to make the …

Hetero Diels±Alder reactions are becoming a mainstay of heterocycle and natural product
synthesis. 1 Among these reactions, the imino Diels±Alder provides a rapid means of …

The extent of the binocular cortical field in albino mice, as revealed by recording from single
cells, was almost normal; although the input from the ipsilateral eye was weaker than normal…