The antibody aducanumab reduces Aβ plaques in Alzheimer's disease

…, R Dunstan, S Salloway, T Chen, Y Ling, J O'Gorman… - Nature, 2016 - nature.com
Alzheimer’s disease (AD) is characterized by deposition of amyloid-β (Aβ) plaques and
neurofibrillary tangles in the brain, accompanied by synaptic dysfunction and neurodegeneration…

Safety and efficacy of anti-tau monoclonal antibody gosuranemab in progressive supranuclear palsy: a phase 2, randomized, placebo-controlled trial

…, MJ Wald, DL Graham, L Gedney, J O'Gorman… - Nature medicine, 2021 - nature.com
A randomized, double-blind, placebo-controlled, 52-week study (no. NCT03068468)
evaluated gosuranemab, an anti-tau monoclonal antibody, in the treatment of progressive …

Mentoring functions: A contemporary view of the perceptions of mentees and mentors

JL Fowler, JG O'Gorman - British journal of Management, 2005 - Wiley Online Library
The purpose of this study was to develop an instrument for assessing mentoring based in
contemporary organizational life. In the first phase of the study, 24 mentees and 24 mentors …

[HTML][HTML] First-in-human, double-blind, placebo-controlled, single-dose escalation study of aducanumab (BIIB037) in mild-to-moderate Alzheimer's disease

…, K Leitermann, A Mikulskis, J O'Gorman… - Alzheimer's & Dementia …, 2016 - Elsevier
Introduction Aducanumab (BIIB037), a human monoclonal antibody selective for aggregated
forms of amyloid beta, is being investigated as a disease-modifying treatment for …

Extending the utility of the Depression Anxiety Stress scale by examining its psychometric properties in Chinese settings

…, J Huang, Y Wang, Q Zhao, DHK Shum, J O'Gorman… - Psychiatry …, 2012 - Elsevier
The Depression Anxiety Stress scale (DASS) is a widely used instrument for assessing
mental health status, but the construct validity of the Chinese version of the test has not been …

BG-12 (dimethyl fumarate): a review of mechanism of action, efficacy, and safety

…, J Zambrano, RH Scannevin, J O'Gorman… - … medical research and …, 2014 - Taylor & Francis
Background: Multiple sclerosis (MS) is a chronic inflammatory disease, affecting more than
2.5 million people worldwide with more 400,000 cases in the United States alone. There has …

Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial

…, KK Muralidharan, DL Graham, J O'Gorman… - The Lancet …, 2019 - thelancet.com
Background Progressive supranuclear palsy is a rare neurodegenerative disease associated
with dysfunctional tau protein. BIIB092 is a humanised monoclonal antibody that binds to N…

Construct validity of the acquired capability for suicide scale: Factor structure, convergent and discriminant validity

J Rimkeviciene, J Hawgood, J O'Gorman… - Journal of …, 2017 - Springer
The Acquired Capability for Suicide Scale (ACSS) assesses one of three main constructs in
the Interpersonal Theory of Suicide but evidence of its validity is limited. In two studies (Ns = …

Personal stigma in suicide attempters

J Rimkeviciene, J Hawgood, J O'Gorman… - Death studies, 2015 - Taylor & Francis
The aim of this study was to explore suicide attempters’ experiences of personal stigma.
This qualitative study included a focus group of 7 experienced clinicians and semi-structured …

The relationship between mentee‐mentor gender combination and the provision of distinct mentoring functions

…, AJ Gudmundsson, JG O'Gorman - Women in Management …, 2007 - emerald.com
Purpose – The purpose of this paper is to investigate the relationships between specific
gender combinations of mentor‐mentee and distinct mentoring functions. Design/methodology/…