Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders

A Zhang, JL Neumeyer, RJ Baldessarini - Chemical reviews, 2007 - ACS Publications
Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system (CNS).
The cerebral dopaminergic system is implicated in the pathophysiology of several …

SPECT imaging of dopamine and serotonin transporters with [123I]β‐CIT: Pharmacological characterization of brain uptake in nonhuman primates

…, RC Zimmermann, G Wisniewski, JL Neumeyer… - Synapse, 1993 - Wiley Online Library
Single photon emission computed tomography (SPECT) studies of regional kinetic uptake
and pharmacological specificity of [ 123 I] methyl 3β‐ (4‐iodophenyl) tropane‐2β‐carboxylate (…

Graphical, Kinetic, and Equilibrium Analyses of in vivo [123I]β-CIT Binding to Dopamine Transporters in Healthy Human Subjects

…, SS Zoghbi, JL Neumeyer… - Journal of Cerebral …, 1994 - journals.sagepub.com
The in vivo kinetics of the dopamine (DA) transporter probe 123 I-labeled 2β-carboxymethoxy-3β-(4-iodophenyl)tropane
([ 123 I]β-CIT) in striatum was investigated with single-photon …

N-. omega.-fluoroalkyl analogs of (1R)-2. beta.-carbomethoxy-3. beta.-(4-iodophenyl) tropane (. beta.-CIT): radiotracers for positron emission tomography and single …

JL Neumeyer, A Campbell, S Wang… - Journal of medicinal …, 1994 - ACS Publications
Imaging techniques are increasingly applied to neuro-chemical and neuropharmacological
studies of brain function. PET (positron emission tomography) and SPECT (single photon …

Advances in development of dopaminergic aporphinoids

…, RJ Baldessarini, JL Neumeyer - Journal of medicinal …, 2007 - ACS Publications
Aporphine alkaloids constitute one of the largest groups of isoquinolines, with more than 500
structures reported to date. Structures of these alkaloids include aporphines, proaporphines…

Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines

JL Neumeyer, NS Kula, J Bergman… - European journal of …, 2003 - Elsevier
We prepared a series of 18 novel substituted phenylbenzazepine congeners of the
dopamine D1/D5 receptor partial-agonist SKF-83959 (R,S-3-methyl-6-chloro-7,8-dihydroxy-1-[3′-…

[PDF][PDF] Cocaine receptors labeled by [3H] 2-carbomethoxy-3-(4-fluorophenyl) tropane

…, RD Spealman, MA Fahey, JL Neumeyer… - Mol …, 1989 - researchgate.net
The potent cocaine analog 2fl-carbomethoxy-3fl-(4-fluorophenyl)-tropane(CFT, also designated
WIN 35,428) was tritiated and evaluated as a molecular probe for cocaine receptors in …

Radiosynthesis of [18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane and the first human study with positron emission tomography

…, A Yee, S Wang, G Tamagnan, JL Neumeyer… - Nuclear medicine and …, 1996 - Elsevier
A procedure for the routine preparation of [ 18 F]FP-CIT has been developed. Purification of
the final product was achieved by preparative HPLC using phenethyl column without …

In vivo imaging of baboon and human dopamine transporters by positron emission tomography using [11C]WIN 35,428

…, T Folio, U Scheffel, GA Ricaurte, JL Neumeyer… - Synapse, 1993 - Wiley Online Library
[ 11 C]WIN 35,428 was evaluated as a specific in vivo radioligand for the dopamine transporter
site by PET scanning in nonhuman primates and humans. In studies with a baboon (…

[PDF][PDF] Update 1 of: Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders

N Ye, JL Neumeyer, RJ Baldessarini, X Zhen, A Zhang - Chem. Rev, 2013 - academia.edu
Dopamine (DA) is a critical neurotransmitter in the mammalian central nervous system (CNS).
The cerebral dopaminergic system is implicated in the pathophysiology of several …