Background: A growing body of preclinical research suggests that brain glutamate systems
may be involved in the pathophysiology of major depression and the mechanism of action of …

A considerable body of evidence has accumulated over recent years on the functions of the
default-mode network (DMN) – a set of brain regions whose activity is high when the mind is …

• To evaluate possible abnormal noradrenergic neuronal regulation in patients with
posttraumatic stress disorder (PTSD), the behavioral, biochemical, and cardiovascular effects of …

Background Exercise is known to be associated with reduced risk of all-cause mortality,
cardiovascular disease, stroke, and diabetes, but its association with mental health remains …

The unpredictability and uncertainty of the COVID-19 pandemic; the associated lockdowns,
physical distancing, and other containment strategies; and the resulting economic …

Background The analysis of repeated-measures data presents challenges to investigators
and is a topic for ongoing discussion in theArchives of General Psychiatry.Traditional methods …

Background: To characterize further behavioral, cognitive, neuroendocrine, and physiological
effects of subanesthetic doses of ketamine hydrochloride in healthy human subjects. …

The dopamine hypothesis of schizophrenia proposes that hyperactivity of dopaminergic
transmission is associated with this illness, but direct observation of abnormalities of dopamine …

OBJECTIVE: The authors previously observed an increase in striatal dopamine transmission
following amphetamine challenge in 15 untreated patients with schizophrenia compared to …

Depression is a common, devastating illness. Current pharmacotherapies help many patients,
but high rates of a partial response or no response, and the delayed onset of the effects of …