Prompt diagnosis of rupture and impending rupture of abdominal aortic aneurysms is imperative.
The computed tomographic (CT) findings of ruptured abdominal aortic aneurysms are …

B-cell chronic lymphocytic leukemia (B-CLL) represents a neoplastic disorder caused primarily
by defective programmed cell death (PCD), as opposed to increased cell proliferation. …

Background Fludarabine is an effective treatment for chronic lymphocytic leukemia that does
not respond to initial treatment with chlorambucil. We compared the efficacy of fludarabine …

BRD4, a bromodomain and extraterminal domain (BET) family member, is an attractive target
in multiple pathological settings, particularly cancer. While BRD4 inhibitors have shown …

Fludarabine and rituximab combination therapies in chronic lymphocytic leukemia (CLL)
have yielded promising early results, but no comparative efficacy data relative to standard …

Proteolysis Targeting Chimera (PROTAC) technology is a rapidly emerging alternative
therapeutic strategy with the potential to address many of the challenges currently faced in …

Inhibiting protein function selectively is a major goal of modern drug discovery. Here, we
report a previously understudied benefit of small molecule proteolysis-targeting chimeras (…

Small molecule-induced protein degradation is an attractive strategy for the development of
chemical probes. One method for inducing targeted protein degradation involves the use of …

Proteolysis targeting chimera (PROTAC) technology has emerged over the last two decades
as a powerful tool for targeted degradation of endogenous proteins. Herein we describe the …

Hedeager's aim in this document is to use archaeology, basically the analysis of the material
from approximately 10,000 graves, hoards, and loose finds, to throw some light upon the …