Object. Syringomyelia causes progressive myelopathy. Most patients with syringomyelia
have a Chiari I malformation of the cerebellar tonsils. Determination of the pathophysiological …

Primary CNS lymphoma (PCNSL) harbors mutations that reinforce B cell receptor (BCR)
signaling. Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, targets BCR signaling and is …

Brain tumor-associated cerebral edema arises because tumor capillaries lack normal blood-brain
barrier function; vascular permeability factor (VPF, also known as vascular endothelial …

Study Design. Case report and literature review. Objectives. Clinicians use methylmethacrylate
vertebroplasty to treat vertebral hemangiomas, metastases, and osteoporotic fractures. …

A significant number of patients with progressive leukodystrophy do not have a definitive
diagnosis. This report describes the clinical, morphological, and biochemical characteristics of …

PURPOSE: To describe the technique and results of injecting ethanol directly into symptomatic
vertebral hemangiomas. MATERIALS AND METHODS: Eleven patients with paraplegia (…

Vascular endothelial growth factor (VEGF) is an angiogenic growth factor that also induces
vascular permeability and macrophage migration. VEGF expression is weak in normal adult …

Nanotechnology is the design and assembly of submicroscopic devices called nanoparticles,
which are 1–100 nm in diameter. Nanomedicine is the application of nanotechnology for …

Background Human herpesvirus-6 (HHV-6) is a β-herpesvirus with 90% seroprevalence
that infects and establishes latency in the central nervous system. Two HHV-6 variants are …

… John Heiss at NINDS, the NIH clinical center pharmacy, and other staff at the NIH clinical
center are participating in the execution of the clinical protocol. The NIH/NCATS Office …